Role of hemopoietic growth factors in regeneration of hemopoiesis during etoposide-induced myelosuppression

被引：0

作者：

Udut E.V. ^{[1
]}

Zhdanov V.V. ^{[1
]}

Gur'yantseva L.A. ^{[1
]}

Dygai A.M. ^{[1
]}

Gol'dberg V.E. ^{[1
]}

Tkachenko S.B. ^{[1
]}

机构：

[1] Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

来源：

Bulletin of Experimental Biology and Medicine | 2001年 / 131卷 / 5期

关键词：

Colony-stimulating activity; Erythropoietic activity; Etoposide; Hemopoietic microenvironment;

D O I：

10.1023/A:1017959528320

中图分类号：

学科分类号：

摘要：

We studied structural and functional organization of the bone marrow, production of hemopoietic growth factors by hemopoietic cells, and plasma colony-stimulating and erythropoietic activities in CBA/CaLac mice treated with etoposide. The effects of etoposide on cultured hemopoietic and microenvironmental cells were also evaluated. Our results indicate that hemopoietic growth factors secreted by adherent bone marrow cells play the major role in the normalization of hemopoiesis during etoposide-induced myelosuppression.

引用

页码：432 / 436

页数：4

共 9 条

[1] Gol'dberg E.D., Dygai A.M., Zhdanov V.V., Role of Hemopoietic Microenvironment in the Regulation of Hemopoiesis During Cytostatic Myelosuppressions, (1999)
[2] Gol'berg E.D., Dygai A.M., Shakhov V.P., Tissue Cultures in Hematology, (1992)
[3] Gol'berg E.D., Dygai A.M., Shakhov V.P., Role of Cell-Cell Interactions in the Regulation of Hemopoiesis, (1989)
[4] Karpova G.V., Fomina T.I., Timina E.A., Et al., Eksp. Klin. Farmakol., 61, 2, (1998)
[5] Lakin G.F., Biometry, (1973)
[6] Pavlova E.D., Vepeside (etoposide) in chemotherapy of lung cancer and malignant germinogenic testicular tumors, (1990)
[7] Timina E.A., Myelotoxicity of Vepeside, (1998)
[8] Gordon M.Y., Br. J. Haematol., 70, pp. 1-4, (1988)
[9] Soni N., Meropol N.J., Pendyala L., Et al., J. Clin. Oncol., 15, 2, pp. 766-772, (1997)

← 1 →