N-Doped graphene quantum dot@mesoporous silica nanoparticles modified with hyaluronic acid for fluorescent imaging of tumor cells and drug delivery

被引：0
作者：
Wenying Gui
Jinrui Zhang
Xueqian Chen
Dahai Yu
Qiang Ma
机构：
[1] Jilin University,Department of Analytical Chemistry, College of Chemistry
[2] Jilin University,Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of life Science
来源：
Microchimica Acta | 2018年 / 185卷
关键词：
Doxorubicin; CD-44; Photoluminescence; Förster resonance energy transfer; HeLa; Nanoparticles; Nanocarrier; Fluorescence quenching; Target recognition; Drugs loading;
D O I：
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中图分类号：
学科分类号：
摘要：
The authors describe new bifunctional mesoporous silica nanoparticles (NPs) for specific targeting of tumor cells and for intracellular delivery of the cancer drug doxorubicin (DOX). Mesoporous silica nanoparticles (MSNPs) were coated with blue fluorescent N-graphene quantum dots, loaded with the drug DOX, and finally coated with hyaluronic acid (HA). Cellular uptake of the NPs with an architecture of the type HA-DOX-GQD@MSNPs enabled imaging of human cervical carcinoma (HeLa) cells via fluorescence microscopy. The cytotoxicity of the nanoparticles on HeLa cells was also assessed. The results suggest that the NPs are higher cytotoxicity effect and exert in living cell imaging ability. Compared to the majority of other drug nanocarrier systems, the one described here enables simultaneous DOX release and fluorescent monitoring.
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[1]  
Hocinea O(2010)Silicalites and mesoporous silica nanoparticles for photodynamic therapy Int J Pharm 402 221-230
[2]  
Gary-Bobod M(2017)A positive feedback strategy for enhanced chemotherapy based on ROS-triggered self-accelerating drug release nanosystem Biomaterials 128 136-146
[3]  
Breveta D(2015)Nuclear-targeting MSNs-based drug delivery system: global gene expression analysis on the MDR-overcoming mechanisms Adv Healthcare Mater 4 2641-2648
[4]  
Maynadierd M(2007)Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: preparation and fluorescein isothiocyanate (FITC) release kinetics Colloids Surf B: Biointerfaces 58 180-187
[5]  
Fontaneld S(2015)Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy Adv Drug Deliv Rev 95 40-49
[6]  
Raehma L(2011)Nanoparticles for intracellular-targeted drug delivery Nanotechnology 22 494002-494012
[7]  
Richetera S(2015)Enhancing cellular uptake and doxorubicin delivery of mesoporous silica nanoparticles via surface functionalization: effects of serum ACS Appl Mater Interfaces 7 26880-26891
[8]  
Loockh B(2015)Facile preparation of pH-sensitive and self-fluorescent mesoporous silica nanoparticles modified with PAMAM dendrimers for label-free imaging and drug delivery Chem Eng J 266 171-178
[9]  
Couleaudj P(2006)Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells J Am Chem Soc 128 14792-14793
[10]  
Frochotj C(2009)Targeting of porous hybrid silica nanoparticles to cancer cells ACS Nano 3 197-206
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