Granulomatosis with Polyangiitis in Childhood

被引:0
作者
Marinka Twilt
Susanne Benseler
David Cabral
机构
[1] University of Toronto,Division of Rheumatology, Department of Pediatrics and Child Health Evaluative Sciences, Research Institute, the Hospital for Sick Children
[2] University of British Columbia and British Columbia Children’s Hospital,Division of Rheumatology, Department of Pediatrics
来源
Current Rheumatology Reports | 2012年 / 14卷
关键词
Granulomatosis with polyangiitis (GPA); Childhood granulomatous vasculitis; Vasculitis; Childhood; Wegener’s granulomatosis; Antineutrophil cytoplasmic antibodies (ANCA); ANCA-associated vasculitis (AAV);
D O I
暂无
中图分类号
学科分类号
摘要
Granulomatosis with polyangiitis (GPA) is a rare yet frequently organ- or life-threatening systemic vasculitis affecting small- to medium-sized arteries in multiple organs. It characteristically leads to alveolar hemorrhage and destructive, pauci-immune glomerulonephritis. GPA is also characterized by granulomas in the upper and lower respiratory tract causing erosive sinusitis and nodular or even cavitating lesions in the respiratory tract. Antineutrophil cytoplasmic antibodies, a hallmark of GPA, are likely integral to the pathogenesis and recently have become a therapeutic target. International collaborations in childhood vasculitis have led to the development and validation of childhood vasculitis classification criteria, advanced our understanding of the clinical phenotype at presentation of GPA, and improved our ability to capture disease activity and determine treatment choices. Treatment efficacy and safety data continue to be largely derived from adult GPA studies. This review focuses on the recent publications on epidemiology, pathogenesis, and treatment in childhood GPA and relevant publications from the adult GPA literature.
引用
收藏
页码:107 / 115
页数:8
相关论文
共 50 条
[41]   Granulomatosis With Polyangiitis Presenting as Acute Compartment Syndrome [J].
Pumerantz, Aaron W. ;
Stout, Brian J. ;
Tracy, Christopher L. .
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2016, 22 (04) :225-228
[42]   Frequency, Diagnosis, Treatment, and Outcome of Gastrointestinal Disease in Granulomatosis with Polyangiitis and Microscopic Polyangiitis [J].
Eriksson, Per ;
Segelmark, Marten ;
Hallbook, Olof .
JOURNAL OF RHEUMATOLOGY, 2018, 45 (04) :529-537
[43]   Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis [J].
Youssef, Michael ;
Sedarous, Mary ;
Grin, Andrea ;
Chung, Andrew ;
Hookey, Lawrence .
ACG CASE REPORTS JOURNAL, 2023, 10 (02)
[44]   Three Patterns of Cutaneous Involvement in Granulomatosis with Polyangiitis [J].
Ragab, Gaafar ;
Hegazy, Mohamed Tharwat ;
Ali, Mohamed ;
Abdel-Halim, Mona R. E. ;
Puechal, Xavier .
JOURNAL OF ADVANCED RESEARCH, 2020, 24 :311-315
[45]   Adolescent with severe granulomatosis with polyangiitis: a case report [J].
Arfaoui, Hajar ;
Elkihal, Hamza ;
Jabri, Hasna ;
Elkhattabi, Wiam ;
Afif, Hicham .
PAN AFRICAN MEDICAL JOURNAL, 2021, 38
[46]   Aortic Valve Involvement in a Patient With Granulomatosis With Polyangiitis [J].
Singh, Gurmeet ;
Bali, Surinder Kumar ;
Koul, Varsha .
ARCHIVES OF RHEUMATOLOGY, 2014, 29 (03) :232-235
[47]   Eosinophilic granulomatosis with polyangiitis (ChurgStrauss): state of the art [J].
Vaglio, A. ;
Buzio, C. ;
Zwerina, J. .
ALLERGY, 2013, 68 (03) :261-273
[48]   Granulomatosis with polyangiitis presenting with pachymeningitis and persistent headache [J].
Cotelli, Maria Sofia ;
Scarsi, Mirko ;
Bianchi, Marta ;
Bertasi, Valeria ;
Civelli, Patrizia ;
Manelli, Filippo ;
Turla, Marinella .
ITALIAN JOURNAL OF MEDICINE, 2020, 14 (01) :27-30
[49]   Advances in the pharmacotherapeutic management of eosinophilic granulomatosis with polyangiitis [J].
Pagnoux, Christian ;
Berti, Alvise .
EXPERT OPINION ON PHARMACOTHERAPY, 2023, 24 (11) :1269-1281
[50]   Establishing the Feasibility of Face Transplantation in Granulomatosis With Polyangiitis [J].
Hashem, A. M. ;
Hoffman, G. S. ;
Gastman, B. ;
Bernard, S. ;
Djohan, R. ;
Hendrickson, M. ;
Schwarz, G. ;
Doumit, G. ;
Gharb, B. B. ;
Rampazzo, A. ;
Zins, J. E. ;
Siemionow, M. ;
Papay, F. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (07) :2213-2223