Dopamine D1 receptors regulate the extracellular citrulline level in the nucleus accumbens during performance of a conditioned reflex fear reaction

被引：1

作者：

Saul'kaya N.B. ^{[1
]}

Fofonova N.V. ^{[1
]}

机构：

[1] I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg

来源：

Neuroscience and Behavioral Physiology | 2009年 / 39卷 / 4期

基金：

俄罗斯基础研究基金会;

关键词：

Behavior; Citrulline; Dopamine; Intracerebral microdialysis; Nitric oxide; Ventral striatum;

D O I：

10.1007/s11055-009-9145-3

中图分类号：

学科分类号：

摘要：

Intracerebral microdialysis studies on Sprague-Dawley rats using HPLC showed that performance of a conditioned reflex fear reaction was accompanied by an increase in the extracellular citrulline (a co-product of nitric oxide synthesis) level in the nucleus accumbens. Administration of the selective D1 receptor antagonist SCH-23390 (100 μM) into the nucleus accumbens had no long-lasting effect on the extracellular citrulline level in this structure, but reduced the magnitude of the increase in the citrulline level seen on performance of the conditioned reflex fear reaction. These data suggest that the dopaminergic input of the nucleus accumbens acts via D1 receptors to increase NO synthase activity and nitric oxide production during performance of the conditioned reflex fear reaction. © 2009 Springer Science+Business Media, Inc.

引用

页码：335 / 340

页数：5

共 14 条

[1] Savel'ev S.A., Repkina N.S., Saul'skaya N.B., A sensitive method for assaying citrulline for vital monitoring of nitric oxide production in the CNS, Ros. Fiziol. Zh. Im. I. M. Sechenova, 91, 5, pp. 587-591, (2005)
[2] Saul'skaya N.B., Savel'ev S.A., Solov'eva N.A., Fofonova N.V., N-synthase-dependent increase in extracellular citrulline levels in the nucleus accumbens during an emotional conditioned response, Ros. Fiziol. Zh. Im. I. M. Sechenova, 92, 6, pp. 700-708, (2006)
[3] Saul'skaya N.B., Fofonova N.V., Savelev S.A., Glutamatergic regulation of extracellular citrulline in the nucleus accumbens during an emotional conditioned response, Ros. Fiziol. Zh. Im. I. M. Sechenova, 93, 6, pp. 635-642, (2007)
[4] Bashkatova V., Kraus M.M., Vanin A., Philippa A., Prast H., 7-Nitroindazole, nNOS inhibitor, attenuates amphetamine-induced amino acid release and nitric oxide generation but not lipid peroxidation in the rat brain, J. Neural Transm., 112, 6, pp. 779-788, (2005)
[5] Bredt D., Hwang P.M., Snyder S.H., Localization of nitric oxide synthase indicating a neural role for nitric oxide, Nature, 347, pp. 768-770, (1990)
[6] Garthwaite J., Glutamate, nitric oxide and cell-cell signaling in the nervous system, Trends Neurosci, 14, pp. 60-67, (1991)
[7] Hidaka S., Totterdell S., Ultrastructural features of the nitric oxide synthase-containing interneurons in the nucleus accumbens and their relationship with tyrosine hydroxylase containing terminals, J. Comp. Neurol., 431, 2, pp. 139-154, (2001)
[8] Kawaguchi Y., Wilson C.J., Augood S.J., Emson P.C., Striatal interneurones: Chemical, physiological and morphological characterization, Trends Neurosci, 18, 12, pp. 527-535, (1995)
[9] Palmer R.M.J., Ferrige A.G., Moncada S., Nitric oxide release accounts for the biological activity of endothelium derived relaxation factor, Nature, 327, pp. 524-526, (1987)
[10] Roitman M.F., Wheeler R.A., Carelli R.M., Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output, Neuron, 45, pp. 587-597, (2004)

← 1 2 →