Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update

被引：0
作者：
Yicheng Yang
Zhiyao Wei
Changming Xiong
Haiyan Qian
机构：
[1] National Center for Cardiovascular Diseases of China,Center for Coronary Heart Disease, Department of Cardiology, Fuwai Hospital
[2] State Key Laboratory of Cardiovascular,Center for Pulmonary Vascular Diseases, Department of Cardiology, Fuwai Hospital
[3] National Center for Cardiovascular Diseases of China,Fuwai Hospital
[4] State Key Laboratory of Cardiovascular,undefined
[5] National Center for Cardiovascular Diseases,undefined
[6] Chinese Academy of Medical Sciences and Peking Union Medical College,undefined
来源：
Virology Journal | / 19卷
关键词：
SARS-CoV-2; COVID-19; Myocardial injury; Cardiomyocytes;
D O I：
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学科分类号：
摘要：
Myocardial injury induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reportedly related to disease severity and mortality, attracting attention to exploring relevant pathogenic mechanisms. Limited by insufficient evidence, myocardial injury caused by direct viral invasion of cardiomyocytes (CMs) is not fully understood. Based on recent studies, endosomal dependence can compensate for S protein priming to mediate SARS-CoV-2 infection of CMs, damage the contractile function of CMs, trigger electrical dysfunction, and tip the balance of the renin–angiotensin–aldosterone system to exert a myocardial injury effect. In this review, we shed light on the direct injury caused by SARS-CoV-2 to provide a comprehensive understanding of the cardiac manifestations of coronavirus disease 2019 (COVID-19).
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