Influence of atrial natriuretic peptide, brain natriuretic peptide and urodilatin on the histamine-induced bronchoconstriction in the conscious guinea pig

被引：1
作者：
Hermel M. [1 ]
机构：
[1] 50737 Koln
来源：
InflammoPharmacology | 1998年 / 6卷 / 2期
关键词：
Guinea pig; Histamine bronchoconstriction; Lung function; Natriuretic peptides;
D O I：
10.1007/s10787-998-0032-2
中图分类号：
学科分类号：
摘要：
The influence of human atrial natriuretic peptide (ANP) and of two related peptides, human brain natriuretic peptide (BNP) and urodilatin (URO) on the bronchoconstriction induced by inhalation of histamine in conscious, non-anaesthetized guinea pigs was tested. Changes in lung function were registered using two independent methods, one operating in a closed body- plethysmographic system, the other in an open system based on the time lag of air flow curves. The peptides were infused (0.25 ml/min) into the jugular vein for a period from 10 min before until 15 min after the histamine inhalation. ANP displayed virtually no effect on the bronchoconstriction. URO showed some inibition at 1280 ng kg-1 min-1, but not at lower doses. BNP (640 ng kg-1 min-1) inhibited the bronchoconstriction markedly for the total registration period. It can be concluded from these results that BNP exerts bronchoprotective effects in the conscious guinea pig, which are superior to those of ANP or URO.
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页码：159 / 178
页数：19
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  • [1] Bold AJ, Borenstein HB, Veress AT, Sonnenberg H, A rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats, Life Sci., 28, pp. 89-94, (1981)
  • [2] Currie MG, Geller DM, Cole BR, Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria, Science, 221, pp. 71-3, (1983)
  • [3] Kangawa K, Matsuo H, Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP), Biochem Biophys Res Commun, 118, 1, pp. 131-9, (1984)
  • [4] Flynn TG, Bold ML, Bold AJ, The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties, Biochem Biophys Res Commun, 117, 3, pp. 859-65, (1983)
  • [5] Seidah NG, Lazure C, Chretien M, Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms, Proc Natl Acad Sci USA, 81, pp. 2640-4, (1984)
  • [6] Harris PJ, Thomas D, Morgan TO, Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption, Nature, 326, pp. 697-8, (1987)
  • [7] Rocha AS, Kudo LH, Atrial peptide and cGMP effects on NaCl transport in innermedullary collecting duct, Am J Physiol, 259, pp. F258-F68, (1990)
  • [8] Cogan MG., Atrial natriuretic peptide can increase renal solute excretion primarily by raising glomerular filtration, Am J Physiol, 250, pp. F710-F14, (1986)
  • [9] Winquist RJ, Faison EP, Nutt RF, Vasodilator profile of synthetic atrial natriuretic factor, Eur J Pharmacol, 102, pp. 169-73, (1984)
  • [10] Sasaki A, Kida O, Kangawa K, Matsuo H, Tanaka K, Involvement of sympathetic nerves in cardiosuppressive effects of human atrial natriuretic peptide in anesthetized rats, Eur J Pharmacol, 120, pp. 345-9, (1986)
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