Potential cytotoxic and apoptosis inducing agents: synthesis and evaluation of methoxy-substituted chalcones against human lung and cervical cancers

被引：0
作者：
K. R. Ethiraj
Jesil Mathew Aranjani
F. Nawaz Khan
机构：
[1] School of Advanced Sciences,Pharmaceutical Chemistry Division
[2] VIT University,Department of Pharmaceutical Biotechnology
[3] Manipal College of Pharmaceutical Sciences,Organic Chemistry Division
[4] Manipal University,undefined
[5] School of Advanced Sciences,undefined
[6] VIT University,undefined
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
Methoxy-substituted chalcones; Cytotoxicity; MTT assay; HeLa; Flow cytometry; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of methoxy group substitution in various positions in both the rings of chalcones on cytotoxicity profile was studied using various synthesized chalcones. The fluorine containing acetophenones when reacted with various methoxy-substituted benzaldehydes in the presence of 10 % sodium hydroxide solution gave the functionalized chalcones. All the synthesized chalcones were confirmed by spectral techniques like FTIR, 1H NMR, 13C NMR, and HRMS studies. All the synthesized compounds were screened for their cytotoxicity against various cell lines. The promising compounds were analyzed for cell cycle analysis.
引用
收藏
页码：5408 / 5417
页数：9
相关论文
共 46 条
  • [31] Design, synthesis and apoptosis inducing effect of novel (Z)-3-(3′-methoxy-4′-(2-amino-2-oxoethoxy)-benzylidene)indolin-2-ones as potential antitumour agents
    Senwar, Kishna Ram
    Reddy, T. Srinivasa
    Thummuri, Dinesh
    Sharma, Pankaj
    Naidu, V. G. M.
    Srinivasulu, Gannoju
    Shankaraiah, Nagula
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 118 : 34 - 46
  • [32] Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an o-methoxy phenyl group as potential agents against gastric cancer
    Gan, Xin
    Wu, Yuna
    Zhu, Min
    Liu, Bo
    Kong, Miaomiao
    Xi, Zixuan
    Li, Ke
    Wang, Haibao
    Su, Tiande
    Yao, Jiali
    Khushafah, Fatehi
    Yi, Baozhu
    Wang, Jiabing
    Li, Wulan
    Wu, Jianzhang
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2024, 39 (01)
  • [33] Light-Mediated Transformation of Renieramycins and Semisynthesis of 4′-Pyridinecarbonyl-Substituted Renieramycin-Type Derivatives as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells
    Sinsook, Suwimon
    Buaban, Koonchira
    Iksen, Iksen
    Petsri, Korrakod
    Innets, Bhurichaya
    Chansriniyom, Chaisak
    Suwanborirux, Khanit
    Yokoya, Masashi
    Saito, Naoki
    Pongrakhananon, Varisa
    Chanvorachote, Pithi
    Chamni, Supakarn
    MARINE DRUGS, 2023, 21 (07)
  • [34] Design, synthesis and biological evaluation of substituted aminopyridazin-3(2H)-ones as G0/G1-phase arresting agents with apoptosis-inducing activities
    Ge, Bing-Chen
    Feng, Hong-Fang
    Cheng, Yu-Fang
    Wang, Hai-Tao
    Xi, Bao-Ming
    Yang, Xue-Mei
    Xu, Jiang-Ping
    Zhou, Zhong-Zhen
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 141 : 440 - 445
  • [35] Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition
    Abd El-Lateef, Hany M.
    Alharbi, Tahani H.
    Fayad, Eman
    Katouah, Hanadi A.
    Elsaid, Fahmy Gad
    Alsunbul, Maha
    Al-Qahtani, Wedad Saeed
    Abu Almaaty, Ali H.
    Gaafar, Ahmed Gaafar Ahmed
    Salama, Mona I.
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1321
  • [36] Design, synthesis and biological evaluation of 8-substituted-6-hydrazonoindolo[2,1-b]quinazolin-12(6H)-one scaffolds as potential cytotoxic agents: IDO-1 targeting molecular docking studies
    Guda, Ramu
    Korra, Rajashekar
    Balaji, Siripireddy
    Palabindela, Rambabu
    Eerla, Rakesh
    Lingabathula, Harikiran
    Yellu, Narsimha Reddy
    Kumar, Girijesh
    Kasula, Mamatha
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (20) : 4741 - 4748
  • [37] Combretastatin A-4 derivatives: synthesis and evaluation of 2,4,5-triaryl-1H-imidazoles as potential agents against H1299 (non-small cell lung cancer cell)
    Tseng, Chih-Hua
    Li, Chi-Yi
    Chiu, Chien-Chih
    Hu, Huei-Ting
    Han, Chein-Hwa
    Chen, Yeh-Long
    Tzeng, Cherng-Chyi
    MOLECULAR DIVERSITY, 2012, 16 (04) : 697 - 709
  • [38] Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis
    Khan, Irfan
    Garikapati, Koteswara Rao
    Shaik, Anver Basha
    Makani, Venkata Krishna Kanth
    Rahim, Abdul
    Shareef, Mohd Adil
    Reddy, V. Ganga
    Pal-Bhadra, Manika
    Kamal, Ahmed
    Kumar, C. Ganesh
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 144 : 104 - 115
  • [39] Rapid and Facile Microwave-Assisted Synthesis of Palladium Nanoparticles and Evaluation of Their Antioxidant Properties and Cytotoxic Effects Against Fibroblast-Like (HSkMC) and Human Lung Carcinoma (A549) Cell Lines
    Ameri, Atefeh
    Shakibaie, Mojtaba
    Rahimi, Hamid-Reza
    Adeli-Sardou, Mahboubeh
    Raeisi, Mahsa
    Najafi, Amir
    Forootanfar, Hamid
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2020, 197 (01) : 132 - 140
  • [40] Rapid and Facile Microwave-Assisted Synthesis of Palladium Nanoparticles and Evaluation of Their Antioxidant Properties and Cytotoxic Effects Against Fibroblast-Like (HSkMC) and Human Lung Carcinoma (A549) Cell Lines
    Atefeh Ameri
    Mojtaba Shakibaie
    Hamid-Reza Rahimi
    Mahboubeh Adeli-Sardou
    Mahsa Raeisi
    Amir Najafi
    Hamid Forootanfar
    Biological Trace Element Research, 2020, 197 : 132 - 140
12345