Potential cytotoxic and apoptosis inducing agents: synthesis and evaluation of methoxy-substituted chalcones against human lung and cervical cancers

被引：0
|
作者：
K. R. Ethiraj
Jesil Mathew Aranjani
F. Nawaz Khan
机构：
[1] School of Advanced Sciences,Pharmaceutical Chemistry Division
[2] VIT University,Department of Pharmaceutical Biotechnology
[3] Manipal College of Pharmaceutical Sciences,Organic Chemistry Division
[4] Manipal University,undefined
[5] School of Advanced Sciences,undefined
[6] VIT University,undefined
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
Methoxy-substituted chalcones; Cytotoxicity; MTT assay; HeLa; Flow cytometry; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of methoxy group substitution in various positions in both the rings of chalcones on cytotoxicity profile was studied using various synthesized chalcones. The fluorine containing acetophenones when reacted with various methoxy-substituted benzaldehydes in the presence of 10 % sodium hydroxide solution gave the functionalized chalcones. All the synthesized chalcones were confirmed by spectral techniques like FTIR, 1H NMR, 13C NMR, and HRMS studies. All the synthesized compounds were screened for their cytotoxicity against various cell lines. The promising compounds were analyzed for cell cycle analysis.
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页码：5408 / 5417
页数：9
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