Synthesis and pharmacological activity of N-[β-(para-substituted benzoyl)ethyl]isoleucine and -methionine

被引：0

作者：

Agababyan A.G. ^{[1
]}

Isakhanyan A.Y. ^{[1
]}

Papoyan O.A. ^{[1
]}

Tumadzhyan A.E. ^{[1
]}

Balasanyan A.S. ^{[1
]}

Gevorgyan G.A. ^{[1
]}

机构：

[1] Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, Yerevan

来源：

Pharmaceutical Chemistry Journal | 2005年 / 39卷 / 7期

关键词：

Ethyl; Organic Chemistry; Hydrochloride; Methionine; Antiinflammatory Activity;

D O I：

10.1007/s11094-005-0156-2

中图分类号：

学科分类号：

摘要：

A series of N-[β-(p-substituted benzoyl)ethyl]-isoleucine and -methionine derivatives have been synthesized via the alkylation of amino acids with p-substituted β-diethylaminopropiophenone hydrochlorides. Some of the synthesized compounds possess significant antiinflammatory activity. © 2005 Springer Science+Business Media, Inc.

引用

页码：364 / 366

页数：2

共 50 条

[31] Synthesis and antiinflammatory and antibacterial activity of β-N-(halogenobenzoyl)-and β-N-(4-methylphenylsulfonyl)hydrazides of 4-Aryl-2-hydroxy-4-oxo-butenoic (aroylpyruvic) acids
Zvereva O.V.
Milyutin A.V.
Bobrovskaya O.V.
Odegova T.F.
Pharmaceutical Chemistry Journal, 2004, 38 (2) : 90 - 92
[32] Substituted amides and hydrazides of dicarboxylic acids. Part 11. Synthesis and pharmacological activity of a series of pyridylamides of dicarboxylic acids
Dolzhenko A.V.
Kolotova N.V.
Koz'minykh V.O.
Syropyatov B.Ya.
Pharmaceutical Chemistry Journal, 2002, 36 (3) : 125 - 127
[33] DESIGN, SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF A NEW INDOMETHACIN ESTER - 2-[N-[3-(3-(PI-PERIDINOMETHYL)PHENOXY)PROPYL]CARBAMOYLMETHYLTHIO]ETHYL 1-(PARA-CHLOROBENZOYL)-5-METHOXY-2-METHYL-INDOLE-3-ACETATE
UEDA, I
ISHII, K
ARAI, H
IKEDA, S
HITOMI, Y
HATANAKA, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1991, 39 (03) : 679 - 684
[34] Reactions of Heterocumulenes with Organometallic Reagents: IX. Synthesis and Rearrangements of N-Allyl-and N-[2-(Vinyloxy)ethyl]-3-butenethioamides and -1-(methylsulfanyl)-3-buten-1-imines
L. L. Dmitrieva
L. P. Nikitina
A. I. Albanov
G. I. Sarapulova
N. A. Nedolya
L. Brandsma
Russian Journal of Organic Chemistry, 2004, 40 : 178 - 187
[35] Synthesis of 2-phenylquinoxaline from α-substituted N-(2-dichloro-2-phenylethyl)arenesulfonamides and o-phenylenediamine
G. N. Rozentsveig
I. B. Rozentsveig
A. N. Mirskova
G. G. Levkovskaya
Russian Journal of Organic Chemistry, 2006, 42 : 458 - 459
[36] Synthesis of 2-phenylquinoxaline from α-substituted N-(2-dichloro-2-phenylethyl)arenesulfonamides and o-phenylenediamine
Rozentsveig, GN
Rozentsveig, IB
Mirskova, AN
Levkovskaya, GG
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 42 (03) : 458 - 459
[37] Synthesis of Substituted 4-Arylsulfonylaminothiazoles from N-(2,2-Dichloro-2-phenyl-1-thioacetylaminoethyl)arenesulfonamides
G. N. Rozentsveig
I. B. Rozentsveig
G. G. Levkovskaya
A. N. Mirskova
Russian Journal of Organic Chemistry, 2003, 39 : 1804 - 1805
[38] Isonicotinoylhydrazothiazoles and isonicotinoyl-N4-substituted thiosemicarbazides:: Synthesis, characterization, and anti-mycobacterial activity
Cardia, Maria Cristina
Distinto, Simona
Maccioni, Elias
Plumitallo, Antonio
Saddi, Manuela
Sanna, Maria Luisa
DeLogu, Alessandro
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 43 (05) : 1337 - 1342
[39] Synthesis and Analgesic Activity of Substituted N-Alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides
Denisova, E. I.
Zvereva, O. V.
Lipin, D. V.
Makhmudov, R. R.
Chernov, I. N.
Denislamova, E. S.
Shipilovskikh, D. A.
Igidov, N. M.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (11) : 2162 - 2169
[40] Synthesis and pharmacological activity of 2-methoxyphenyl- and 2-oxyphenyl-substituted 1-dialkylaminoalkylimidazo [1,2-a]-benzimidazoles
Anisimova V.A.
Tolpygin I.E.
Spasov A.A.
Kosolapov V.A.
Chernikov M.V.
Stepanov A.V.
Larionov V.P.
Pharmaceutical Chemistry Journal, 2005, 39 (11) : 579 - 586

← 1 2 3 4 5 →