The antimicrobial effects of PLGA microspheres containing the antimicrobial peptide OP-145 on clinically isolated pathogens in bone infections

被引：0
作者：
Ye Cheng
Jianhua Qin
Yuliang Huang
Tianyu Wang
机构：
[1] Xinhua Hospital of Zhejiang Province,Department of Orthopaedics
[2] The Second Affiliated Hospital of Zhejiang Chinese Medical University,Department of Rehabilitation
[3] Hangzhou Plastic Surgery Hospital,undefined
[4] Xinhua Hospital of Zhejiang Province,undefined
[5] The Second Affiliated Hospital of Zhejiang Chinese Medical University,undefined
来源：
Scientific Reports | / 12卷
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摘要：
Infection after fracture is a significant problem for the healing of fractures. Antimicrobial peptides combined with PLGA (poly-lactic-co-glycolic acid) microspheres can open new horizons for treating bone infections. Twenty rats in the control group were treated with physiologic saline solution after surgery, and 20 rats in the treatment group were treated with OP-145 PLGA microspheres and vancomycin after surgery. The biofilms from treatment and control groups were analyzed by fluorescence microscopy. Blood samples were collected at 12, 24, 36, 48, and 72 h. OP-145 PLGA microspheres showed significant inhibitory effects on clinically isolated strains (P < 0.05) and there were significant differences in serum CRP (P < 0.05) levels compared with control group. In conclusion, OP-145 PLGA microspheres could slowly release antimicrobial peptides and significantly reduce biofilm formation and levels of inflammatory factors.
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