Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

被引：0
作者：
Esteban A. Gomez
Romain A. Colas
Patricia R. Souza
Rebecca Hands
Myles J. Lewis
Conrad Bessant
Costantino Pitzalis
Jesmond Dalli
机构：
[1] Queen Mary University of London,William Harvey Research Institute, Barts and The London School of Medicine and Dentistry
[2] Queen Mary University of London,Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry
[3] Queen Mary University of London,School of Biological and Chemical Sciences
[4] Queen Mary University of London,Centre for Inflammation and Therapeutic Innovation
来源：
Nature Communications | / 11卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral blood  specialized pro-resolving mediator (SPM) concentrations are linked with both DMARD responsiveness and disease pathotype. Machine learning analysis demonstrates that baseline plasma concentrations of resolvin D4, 10S, 17S-dihydroxy-docosapentaenoic acid, 15R-Lipoxin (LX)A4 and n-3 docosapentaenoic-derived Maresin 1 are predictive of DMARD responsiveness at 6 months. Assessment of circulating SPM concentrations 6-months after treatment initiation establishes that differences between responders and non-responders are maintained, with a decrease in SPM concentrations in patients resistant to DMARD therapy. These findings elucidate the potential utility of  plasma SPM concentrations as biomarkers of DMARD responsiveness in RA.
引用
收藏
相关论文
共 32 条
[31]   Juvenile rheumatoid arthritis synovial fluid immune complexes induce a broad spectrum of pro-inflammatory cytokines from peripheral blood mononuclear cells [J].
Jarvis, JN ;
Wang, WL ;
Xu, CS .
ARTHRITIS AND RHEUMATISM, 1996, 39 (09) :154-154
[32]   Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts [J].
Su, Xiaohui ;
Huang, Qingchun ;
Chen, Jianyu ;
Wang, Maojie ;
Pan, Hudan ;
Wang, Rui ;
Zhou, Hua ;
Zhou, Zhanqing ;
Liu, Juan ;
Yang, Fen ;
Li, Ting ;
Liu, Liang .
PHARMACOLOGICAL RESEARCH, 2016, 113 :695-704
1234