Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

被引：0

作者：

Esteban A. Gomez

Romain A. Colas

Patricia R. Souza

Rebecca Hands

Myles J. Lewis

Conrad Bessant

Costantino Pitzalis

Jesmond Dalli

机构：

[1] Queen Mary University of London,William Harvey Research Institute, Barts and The London School of Medicine and Dentistry

[2] Queen Mary University of London,Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry

[3] Queen Mary University of London,School of Biological and Chemical Sciences

[4] Queen Mary University of London,Centre for Inflammation and Therapeutic Innovation

来源：

Nature Communications | / 11卷

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摘要：

Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral blood specialized pro-resolving mediator (SPM) concentrations are linked with both DMARD responsiveness and disease pathotype. Machine learning analysis demonstrates that baseline plasma concentrations of resolvin D4, 10S, 17S-dihydroxy-docosapentaenoic acid, 15R-Lipoxin (LX)A4 and n-3 docosapentaenoic-derived Maresin 1 are predictive of DMARD responsiveness at 6 months. Assessment of circulating SPM concentrations 6-months after treatment initiation establishes that differences between responders and non-responders are maintained, with a decrease in SPM concentrations in patients resistant to DMARD therapy. These findings elucidate the potential utility of plasma SPM concentrations as biomarkers of DMARD responsiveness in RA.

引用

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