Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives

被引：0
作者：
E. Menteşe
F. Yılmaz
N. Karaali
S. Ülker
B. Kahveci
机构：
[1] Recep Tayyip Erdoǧan University,Department of Chemistry, Art and Science Faculty
[2] Recep Tayyip Erdoǧan University,Department of Biology, Faculty of Arts and Sciences
[3] Karadeniz Technical University,Department of Nutrition and Dietetics, Faculty of Health Sciences
来源：
Russian Journal of Bioorganic Chemistry | 2014年 / 40卷
关键词：
benzimidazole; perimidine; bisbenzimidazole; microwave synthesis; iminoester hydrochloride; lipase inhibition;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H NMR and 13C NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.
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页码：336 / 342
页数：6
相关论文
共 89 条
[1]  
Flegal KM(2012)undefined J. Amer. Med. Assoc. 307 491-497
[2]  
Carroll MD(1997)undefined New Engl. J. Med. 337 581-588
[3]  
Kit BK(2007)undefined Lancet 370 1706-1713
[4]  
Ogden CL(2010)undefined J. Heterocyclic Chem. 47 77-80
[5]  
Connolly HM(2009)undefined Eur. J. Med. Chem. 44 1024-1033
[6]  
Crary McGoon MD(2006)undefined Bioorg. Med. Chem. 14 8271-8279
[7]  
Hensrud DD(2004)undefined Bioorg. Med. Chem. Lett. 17 1007-1010
[8]  
Edwards BS(2010)undefined Eur. J. Med. Chem. 45 2048-2054
[9]  
Edwards WD(1973)undefined Khim.-Farm. Zh. 2 5-2414
[10]  
Schaff HV(1979)undefined Khim.-Farm. Zh. 2 54-1001
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