Preparation and characterization of a new gellan gum and sulphated hyaluronic acid hydrogel designed for epidural scar prevention

被引：0
作者：
Claudia Cencetti
Davide Bellini
Cristina Longinotti
Andrea Martinelli
Pietro Matricardi
机构：
[1] Sapienza University of Rome,Department of Drug Chemistry and Technologies, Faculty of Pharmacy
[2] Sapienza University of Rome,Department of Chemistry
[3] Fidia Advanced Biopolymers s.r.l.,undefined
来源：
Journal of Materials Science: Materials in Medicine | 2011年 / 22卷
关键词：
Hyaluronic Acid; Conductometric Titration; Frequency Sweep Test; Hemolysis Test; L929 Mouse Fibroblast;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Postsurgical adhesions are a common problem in clinical practice, causing nerve compression, pain and discomfort. A new hydrogel based on gellan gum and sulphated hyaluronic acid was synthesized, with the aim to create an effective barrier for epidural scar formation. Physico-chemical properties of the gel were analyzed, and preliminary biocompatibility data (i.e. cytotoxicity) have been collected in view of its potential clinical use. The characterization of the new material demonstrated that the hydrogel, due to its high-viscosity, could effectively act as a barrier with a long in situ residence time. In addition, the hydrogel can be easily extruded from a syringe and its structure exhibits excellent stabilizing properties. Furthermore, biological assays showed that this gel is suitable for further preclinical development.
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页码：263 / 271
页数：8
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