New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

被引：0
|
作者：
Keiko Ogawa
Seikou Nakamura
Kohei Hosokawa
Hanako Ishimaru
Natsuki Saito
Kaori Ryu
Masahiro Fujimuro
Souichi Nakashima
Hisashi Matsuda
机构：
[1] Kyoto Pharmaceutical University,Department of Pharmacognosy
[2] Misasagi,undefined
来源：
Journal of Natural Medicines | 2018年 / 72卷
关键词：
Ranunculaceae; Diterpene; Antiviral activity; HSV-1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.
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页码：439 / 447
页数：8
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