New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

被引：0
|
作者：
Keiko Ogawa
Seikou Nakamura
Kohei Hosokawa
Hanako Ishimaru
Natsuki Saito
Kaori Ryu
Masahiro Fujimuro
Souichi Nakashima
Hisashi Matsuda
机构：
[1] Kyoto Pharmaceutical University,Department of Pharmacognosy
[2] Misasagi,undefined
来源：
Journal of Natural Medicines | 2018年 / 72卷
关键词：
Ranunculaceae; Diterpene; Antiviral activity; HSV-1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.
引用
收藏
页码：439 / 447
页数：8
相关论文
共 50 条
  • [1] New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1
    Ogawa, Keiko
    Nakamura, Seikou
    Hosokawa, Kohei
    Ishimaru, Hanako
    Saito, Natsuki
    Ryu, Kaori
    Fujimuro, Masahiro
    Nakashima, Souichi
    Matsuda, Hisashi
    JOURNAL OF NATURAL MEDICINES, 2018, 72 (02) : 439 - 447
  • [2] In vitro antiviral activity of dermaseptins against herpes simplex virus type-1
    Belaid, A
    Aouni, M
    Khelifa, R
    Trabelsi, A
    Jemmali, M
    Hani, K
    JOURNAL OF MEDICAL VIROLOGY, 2002, 66 (02) : 229 - 234
  • [3] ANTIVIRAL ACTIVITIES OF GLYCYRRHIZIN AND ITS MODIFIED COMPOUNDS AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) AND HERPES-SIMPLEX VIRUS TYPE-1 (HSV-1) INVITRO
    HIRABAYASHI, K
    IWATA, S
    MATSUMOTO, H
    MORI, T
    SHIBATA, S
    BABA, M
    ITO, M
    SHIGETA, S
    NAKASHIMA, H
    YAMAMOTO, N
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1991, 39 (01) : 112 - 115
  • [4] Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
    Jiang, Kai
    Feng, Jing
    Qi, Xia
    Ran, Lili
    Xie, Lixin
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2022, 16 : 4311 - 4323
  • [5] Antiviral Activities of Officinaloside C against Herpes Simplex Virus-1
    Xiao, Ji
    Cai, Miaomiao
    Wang, Yifei
    Ding, Ping
    MOLECULES, 2022, 27 (11):
  • [6] Antiviral Activities of Diarylheptanoids Isolated from Alpinia officinarum against Respiratory Syncytial Virus, Poliovirus, Measles Virus, and Herpes Simplex Virus Type 1 in vitro
    Konno, Katsuhiko
    Sawamura, Rie
    Sun, Yi
    Yasukawa, Ken
    Shimizu, Tomomi
    Watanabe, Wataru
    Kato, Masahiko
    Yamamoto, Ryuichi
    Kurokawa, Masahiko
    NATURAL PRODUCT COMMUNICATIONS, 2011, 6 (12) : 1881 - 1884
  • [7] In vitro antiviral activity of styrylpyrone derivative-incorporated formulations against Herpes simplex virus type-1
    Bahtiar, Adibah Ahamad
    Nor, Norefrina Shafinaz Md
    Ibrahim, Nazlina
    MALAYSIAN JOURNAL OF MICROBIOLOGY, 2016, 12 (03) : 228 - 232
  • [8] Evaluation of in vitro antiviral activity of Chelidonium majus L. against herpes simplex virus type-1
    Monavari, Seyed Hamidreza
    Shahrabadi, Mahmoud Shamsi
    Keyvani, Hossein
    Bokharaei-Salim, Farah
    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, 2012, 6 (20): : 4360 - 4364
  • [9] Antiviral activity of theaflavin digallate against herpes simplex virus type 1
    de Oliveira, Aline
    Prince, Derek
    Lo, Chih-Yu
    Lee, Lee H.
    Chu, Tin-Chun
    ANTIVIRAL RESEARCH, 2015, 118 : 56 - 67
  • [10] Antiviral Activity of Obtained Extracts from Different Parts of Cupressus sempervirens against Herpes Simplex Virus Type 1
    Emami, Seyed Ahmad
    Tayarani-Najaran, Zahra
    Ghannad, Masoud Sabouri
    Karamadini, Pezhman Khajeh
    Karamadini, Mehrangiz Khajeh
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2009, 12 (3-4) : 133 - 139
12345