Quantification of selected monohydroxy metabolites of polycyclic aromatic hydrocarbons in human urine

被引：0
作者：
Libin Liu
Yueping Luo
Junping Bi
Haifang Li
Jin-Ming Lin
机构：
[1] Hunan Province Environmental Monitoring Centre,Key Laboratory of Monitoring for Heavy Metal Pollutants
[2] Tsinghua University,Beijing Key Laboratory of Microanalytical Methods and Instrumentation; Department of Chemistry
来源：
Science China Chemistry | 2015年 / 58卷
关键词：
polycyclic aromatic hydrocarbons; metabolites; human urine; solid-phase microextraction; GC/MS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An analytical method was developed to quantitatively determine selected monohydroxy metabolites of polycyclic aromatic hydrocarbons (PAHs) in human urine. The procedure included enzymatic hydrolysis to cleave the conjugated metabolites, solid-phase microextraction enrichment, and gas chromatography-mass spectrometry analysis. The method proved to be sensitive enough to detect the selected PAH metabolites in human urine.
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页码：1579 / 1584
页数：5
相关论文
共 121 条
[1]  
Liu Y(2007)Continuous-flow microextraction and gas chromatographic-mass spectrometric determination of polycyclic aromatic hydrocarbon compounds in water Anal Chim Acta 585 294-299
[2]  
Hashi Y(2007)Solid-phase extraction with C30-bonded silica for analysis of polycyclic aromatic hydrocarbons in airborne particulate matters by gas chromatography-mass spectrometry J Chromatogr A 1154 74-80
[3]  
Lin JM(2010)Assessment of non-occupational exposure to polycyclic aromatic hydrocarbons through personal air sampling and urinary biomonitoring J Environ Monit 12 1110-1118
[4]  
Li K(1994)Identification of 1-hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatographymass spectrometry Carcinogenesis 15 483-487
[5]  
Li HF(2014)Magnetic graphene oxide as adsorbent for the determination of polycyclic aromatic hydrocarbon metabolites in human urine J Sep Sci 37 2591-2598
[6]  
Maeda T(2007)Determination of phenolic metabolites of polycyclic aromatic hydrocarbons in human urine as their pentafluorobenzyl ether derivatives using liquid chromatographytandem mass spectrometry Anal Chem 79 587-598
[7]  
Lin JM(2002)Biomonitoring of polycyclic aromatic hydrocarbons in human urine J Chromatogr B 778 31-47
[8]  
Li Z(2000)Biomonitoring of environmental polycyclic aromatic hydrocarbon exposure by simultaneous measurement of urinary phenanthrene, pyrene and benzo[ J Chromatogr B 739 225-229
[9]  
Mulholland JA(2001)]pyrene hydroxides Int Arch Occup Environ Health 74 59-62
[10]  
Romanoff LC(2004)Urinary 1-hydroxy pyrene and 2-naphthol concentrations in male Koreans Int Arch Occup Environ Health 77 23-30
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