Development of cataplasmic transdermal drug delivery system containing eutectic mixture of lidocaine and prilocaine

被引：18

作者：

Chun M.-K. ^{[1
]}

Hossain K. ^{[1
]}

Choi S.-H. ^{[1
]}

Ban S.-J. ^{[1
]}

Moon H. ^{[1
]}

Choi H.-K. ^{[1
]}

机构：

[1] BK21 Project Team, College of Pharmacy, Chosun University, Dong-gu, Gwangju, 501-759

来源：

Journal of Pharmaceutical Investigation | 2012年 / 42卷 / 3期

关键词：

Cataplasm; Eutectic mixture; Lidocaine; Prilocaine; Transdermal drug delivery system;

D O I：

10.1007/s40005-012-0023-6

中图分类号：

学科分类号：

摘要：

A novel transdermal drug delivery system with the eutectic mixture of lidocaine and prilocaine was developed. The permeation of lidocaine and prilocaine proportionally increased as the weight ratio of poly(vinyl alcohol) to poly(acrylic acid) changed from 1:1 to 7:1. However, the adhesive property of the matrix significantly degraded over the ratio of 5:1. The incorporation of humectants in the matrix had a noticeable effect on the permeation of lidocaine and prilocaine. The flux of lidocaine increased as the ratio of lidocaine in the eutectic mixture increased. The permeation rate decreased significantly from the cataplasm containing 3. 5:1 and 4:1 ratio of lidocaine to prilocaine due to recrystallization. When total drug concentration of the cataplasm with the ratio of 3:1 increased from 1. 33 to 4 % against adhesive gel weight, the permeation of both lidocaine and prilocaine increased. However, crystallization was observed beyond 2. 66 % w/w of combined drug load. Enhancers were not effective in the present study as most of the enhancer showed very low or no enhancement effect. No significant changes in the appearance and the drug content in the cataplasm were observed for 3 months. © 2012 The Korean Society of Pharmaceutical Sciences and Technology.

引用

页码：139 / 146

页数：7

共 22 条

[21]

Woolfson A.D., Malcolm R.K., Campbell K., Jones D.S., Russell J.A., Rheological, mechanical and membrane penetration properties of novel dual drug systems for percutaneous delivery, J Control Release, 67, pp. 395-408, (2000)

[22]

Yuan X., Capomacchia A.C., The binary eutectic of NSAIDS and two-phase liquid system for enhanced membrane permeation, Pharm Dev Technol, 10, pp. 1-10, (2005)

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