ctDNA guided adjuvant chemotherapy versus standard of care adjuvant chemotherapy after curative surgery in patients with high risk stage II or stage III colorectal cancer: a multi-centre, prospective, randomised control trial (TRACC Part C)

被引：0

作者：

Susanna Slater

Annette Bryant

Hsiang-Chi Chen

Ruwaida Begum

Isma Rana

Maria Aresu

Clare Peckitt

Oleg Zhitkov

Retchel Lazaro-Alcausi

Victoria Borja

Rachel Powell

David Lowery

Michael Hubank

Thereasa Rich

Gayathri Anandappa

Ian Chau

Naureen Starling

David Cunningham

机构：

[1] Royal Marsden Hospital NHS Foundation Trust,

[2] Biomedical Research Centre at the Royal Marsden and the Institute of Cancer Research,undefined

[3] Centre for Molecular Pathology at the The Royal Marsden Hospital and Institute of Cancer Research,undefined

[4] Guardant Health,undefined

[5] INC,undefined

来源：

BMC Cancer | / 23卷

关键词：

Colorectal cancer; ctDNA; Adjuvant chemotherapy; Randomised; Disease free survival;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 48 条

[31] Postoperative hepatic arterial chemotherapy in high-risk patients as adjuvant treatment after resection of colorectal liver metastases - a randomized phase II/III trial – PACHA-01 (NCT02494973) [J].

Diane Goéré ;

Jean-Pierre Pignon ;

Maximiliano Gelli ;

Dominique Elias ;

Léonor Benhaim ;

Frédéric Deschamps ;

Caroline Caramella ;

Valérie Boige ;

Michel Ducreux ;

Thierry de Baere ;

David Malka .

BMC Cancer, 18

[32] Postoperative hepatic arterial chemotherapy in high-risk patients as adjuvant treatment after resection of colorectal liver metastases - a randomized phase II/III trial PACHA-01 (NCT02494973) [J].

Goere, Diane ;

Pignon, Jean-Pierre ;

Gelli, Maximiliano ;

Elias, Dominique ;

Benhaim, Leonor ;

Deschamps, Frederic ;

Caramella, Caroline ;

Boige, Valerie ;

Ducreux, Michel ;

de Baere, Thierry ;

Malka, David .

BMC CANCER, 2018, 18

[33] Long-term Efficacy of S-1 Monotherapy or Capecitabine Plus Oxaliplatin as Adjuvant Chemotherapy for Patients with Stage II or III Gastric Cancer after Curative Gastrectomy: a Propensity Score-Matched Multicenter Cohort Study [J].

Lee, Chang Min ;

Yoo, Moon-Won ;

Son, Young-Gil ;

Oh, Sung Jin ;

Kim, Jong-Han ;

Kim, Hyoung-Il ;

Park, Joong-Min ;

Hur, Hoon ;

Jee, Ye Seob ;

Hwang, Sun-Hwi ;

Jin, Sung-Ho ;

Lee, Sang Eok ;

Park, Ji-Ho ;

Seo, Kyung Won ;

Park, Sungsoo ;

Kim, Chang Hyun ;

Jeong, In Ho ;

Lee, Han Hong ;

Choi, Sung Il ;

Lee, Sang-Il ;

Kim, Chan Young ;

Kim, In-Hwan ;

Son, Myoung-Won ;

Pak, Kyung Ho ;

Kim, Sungsoo ;

Lee, Moon-Soo ;

Min, Jae-Seok .

JOURNAL OF GASTRIC CANCER, 2020, 20 (02) :152-164

[34] Efficacy of oral administration of cystine and theanine in patients with colorectal cancer undergoing capecitabine-based adjuvant chemotherapy after surgery: study protocol for a multi-institutional, randomised, double-blinded, placebo-controlled, phase II trial [J].

Hamaguchi, Reo ;

Tsuchiya, Takashi ;

Miyata, Go ;

Sato, Toshihiko ;

Takahashi, Kenichi ;

Ariyoshi, Keisuke ;

Oyamada, Shunsuke ;

Iwase, Satoru .

BMJ OPEN, 2018, 8 (07)

[35] Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer [J].

Pectasides, Dimitrios ;

Karavasilis, Vasilios ;

Papaxoinis, George ;

Gourgioti, Georgia ;

Makatsoris, Thomas ;

Raptou, Georgia ;

Vrettou, Eleni ;

Sgouros, Joseph ;

Samantas, Epaminontas ;

Basdanis, George ;

Papakostas, Pavlos ;

Bafaloukos, Dimitrios ;

Kotoula, Vassiliki ;

Kalofonos, Haralambos P. ;

Scopa, Chrisoula D. ;

Pentheroudakis, George ;

Fountzilas, George .

BMC CANCER, 2015, 15

[36] Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer [J].

Dimitrios Pectasides ;

Vasilios Karavasilis ;

George Papaxoinis ;

Georgia Gourgioti ;

Thomas Makatsoris ;

Georgia Raptou ;

Eleni Vrettou ;

Joseph Sgouros ;

Epaminontas Samantas ;

George Basdanis ;

Pavlos Papakostas ;

Dimitrios Bafaloukos ;

Vassiliki Kotoula ;

Haralambos P. Kalofonos ;

Chrisoula D. Scopa ;

George Pentheroudakis ;

George Fountzilas .

BMC Cancer, 15

[37] Safety analysis of two different regimens of uracil-tegafur plus leucovorin as adjuvant chemotherapy for high-risk stage II and III colon cancer in a phase III trial comparing 6 with 18 months of treatment: JFMC33-0502 trial [J].

Tsuchiya, Takashi ;

Sadahiro, Sotaro ;

Sasaki, Kazuaki ;

Kondo, Ken ;

Katsumata, Kenji ;

Nishimura, Genichi ;

Kakeji, Yoshihiro ;

Baba, Hideo ;

Morita, Takayuki ;

Koda, Keiji ;

Sato, Seiji ;

Matsuoka, Junji ;

Yamaguchi, Yoshiyuki ;

Usuki, Hisashi ;

Hamada, Chikuma ;

Kodaira, Susumu ;

Saji, Shigetoyo .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 73 (06) :1253-1261

[38] Randomized phase II study of tegafur–uracil/leucovorin versus tegafur–uracil/leucovorin plus oxaliplatin after curative resection of high-risk stage II/III colorectal cancer (SOAC-1101 trial) [J].

Chihiro Kosugi ;

Keiji Koda ;

Nobuhiro Takiguchi ;

Satoru Takaishi ;

Hideaki Miyauchi ;

Nobuo Hirayama ;

Yukihiro Nomura ;

Eisuke Kondo ;

Yohei Kawasaki ;

Yoshihito Ozawa ;

Hisahiro Matsubara .

International Journal of Colorectal Disease, 2021, 36 :1739-1749

[39] Safety analysis of two different regimens of uracil–tegafur plus leucovorin as adjuvant chemotherapy for high-risk stage II and III colon cancer in a phase III trial comparing 6 with 18 months of treatment: JFMC33-0502 trial [J].

Takashi Tsuchiya ;

Sotaro Sadahiro ;

Kazuaki Sasaki ;

Ken Kondo ;

Kenji Katsumata ;

Genichi Nishimura ;

Yoshihiro Kakeji ;

Hideo Baba ;

Takayuki Morita ;

Keiji Koda ;

Seiji Sato ;

Junji Matsuoka ;

Yoshiyuki Yamaguchi ;

Hisashi Usuki ;

Chikuma Hamada ;

Susumu Kodaira ;

Shigetoyo Saji .

Cancer Chemotherapy and Pharmacology, 2014, 73 :1253-1261

[40] S-1 and Oxaliplatin Versus Tegafur-uracil and Leucovorin as Postoperative Adjuvant Chemotherapy in Patients With High-risk Stage III Colon Cancer (ACTS-CC 02): A Randomized, Open-label, Multicenter, Phase III Superiority Trial [J].

Sunami, Eiji ;

Kusumoto, Tetsuya ;

Ota, Mitsuyoshi ;

Sakamoto, Yoshiyuki ;

Yoshida, Kazuhiro ;

Tomita, Naohiro ;

Maeda, Atsuyuki ;

Teshima, Jin ;

Okabe, Michio ;

Tanaka, Chihiro ;

Yamauchi, Junichiro ;

Itabashi, Michio ;

Kotake, Kenjiro ;

Takahashi, Keiichi ;

Baba, Hideo ;

Boku, Narikazu ;

Aiba, Keisuke ;

Ishiguro, Megumi ;

Morita, Satoshi ;

Takenaka, Naruhito ;

Okude, Ryota ;

Sugihara, Kenichi .

CLINICAL COLORECTAL CANCER, 2020, 19 (01) :22-+

← 1 2 3 4 5 →