Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: Nicotine addiction

被引：14

作者：

Wei Zhu ^{[1
]}

Kirk J. Mantione ^{[1
]}

Lihua Shen ^{[1
]}

Brian Lee ^{[1
]}

George B. Stefano ^{[1
]}

机构：

[1] Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568

来源：

Cellular and Molecular Neurobiology | 2006年 / 26卷 / 4期

关键词：

Acetylcholine; Atropine; Endogenous morphine; Ganglia; Invertebrates; Morphine; Nervous tissue; Nicotine; Norlaudanosoline (tetrahydropapaveroline);

D O I：

10.1007/s10571-006-9021-4

中图分类号：

学科分类号：

摘要：

1. Given the presence of morphine, its metabolites and precursors, e.g., norlaudanosoline, in mammalian and invertebrate tissues, it became important to determine if exposing normal excised ganglia to norlaudanosoline would result in increasing endogenous morphine levels. 2. Mytilus edulis pedal ganglia contain 2.2 ± 0.41 ng/g wet weight morphine as determined by high pressure liquid chromatography coupled to electrochemical detection and radioimmunoassay. 3. Incubation of M. edulis pedal ganglia with norlaudanosoline, a morphine precursor, resulted in a concentration- and time-dependent statistical increase in endogenous morphine levels (6.9 ± 1.24 ng/g). 4. Injection of animals with nicotine also increased endogenous morphine levels in a manner that was antagonized by atropine, suggesting that nicotine addictionmay be related to altering endogenous morphine levels in mammals. 5. We surmise that norlaudanosoline is being converted to morphine, demonstrating that invertebrate neural tissue can synthesize morphine. © 2006 Springer Science+Business Media, Inc.

引用

页码：1037 / 1045

页数：8

共 56 条

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