Mechanism of taxane neurotaxicity

被引：114
作者：
Hagiwara H. [1 ]
Sunada Y. [1 ]
机构：
[1] Division of Neurology, Department of Internal Medicine, Kawasaki Medical School, Okayama 701-0192, 577 Matsushima, Kurashiki-City
来源：
Breast Cancer | 2004年 / 11卷 / 1期
关键词：
Axonal sensory neuropathy; Docetaxel; Microtubules; Paditaxel; Taxanes; Tubulins;
D O I：
10.1007/BF02968008
中图分类号：
学科分类号：
摘要：
The two taxanes (paclitaxel and docetaxel) are widely employed in standard antineoplastic practice. Although these agents are now well established, some toxic side effects have been reported. Toxicity of these agents includes bone marrow suppression (principally neutropenia), hypersensitivity reactions, cutaneus reactions, edema and neurotoxicity. The most prominent neurotoxicity is a sensory neuropathy. Controlling neuropathy is crucial for maintaining the quality of life of patients because it is usually persistent and hard to manage. The precise mechanism for taxane-induced neuropathy is still unknown. The taxanes are known to promote aggregation of intracellular microtubules. Abnormal aggregation of microtubules in the neuronal cells may cause this neuropathy. In addition, the taxanes have been suggested to have intrinsic toxicity and directly injure the cells. A better understanding of the mechanism for this neuropathy may improve the quality of life of patients who undergo taxane antineoplastic therapy.
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页码：82 / 85
页数：3
相关论文
共 27 条
  • [11] Letourneau P.C., Shattuck T.A., Ressler A.H., Branching of sensory and sympathetic neurites in vitro is inhibited by treatment with taxol, Journal of Neuroscience, 6, 7, pp. 1912-1917, (1986)
  • [12] Lipton R.B., Apfel S.C., Dutcher J.P., Rosenberg R., Kaplan J., Berger A., Einzig A.I., Wiernik P., Schaumburg H.H., Taxol produces a predominantly sensory neuropathy, Neurology, 39, 3, pp. 368-373, (1989)
  • [13] Postma T.J., Vermorken J.B., Hefting A.J., Pinedo H.M., Heimans J.J., Paclitaxel-induced neuropathy, Ann Oncol, 6, pp. 489-494, (1995)
  • [14] Sahenk Z., Barohn R., New P., Mendell J.R., Taxol neuropathy: Electrodiagnostic and sural nerve biopsy findings, Archives of Neurology, 51, 7, pp. 726-729, (1994)
  • [15] Apfel S.C., Docetaxel neuropathy, Neurology, 46, pp. 2-3, (1996)
  • [16] Hilkens P.H.E., Verweij J., Stoter G., Vecht Ch.J., Van Putten W.L.J., Van Den Bent M.J., Peripheral neurotoxicity induced by docetaxel, Neurology, 46, 1, pp. 104-108, (1996)
  • [17] New P.Z., Jackson C.E., Rinaldi D., Burris H., Barohn R.J., Peripheral neuropathy secondary to docetaxel (Taxotere), Neurology, 46, 1, pp. 108-111, (1996)
  • [18] Hilkens P.H.E., Verweij J., Vecht Ch.J., Stoter G., Van Den Bent M.J., Clinical characteristics of severe peripheral neuropathy induced by docetaxel (Taxotere), Annals of Oncology, 8, 2, pp. 187-190, (1997)
  • [19] Chaudhry V., Chaudhry M., Crawford T.O., Simmons-O'Brien E., Griffin J.W., Toxic neuropathy in patients with pre-existing neuropathy, Neurology, 60, 2, pp. 337-340, (2003)
  • [20] Roytta M., Raine C.S., Taxol-induced neuropathy: Further ultrastructural studies of nerve fiber changes in situ, J Neurocytol, 14, pp. 157-175, (1985)
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