CSF2RA, ANT3, and STS are autosomal in marsupials: implications for the origin of the pseudoautosomal region of mammalian sex chromosomes

被引：0
作者：
Roland Toder
Jennifer A. Marshall Graves
机构：
[1] La Trobe University,School of Genetics and Human Variation
来源：
Mammalian Genome | 1998年 / 9卷
关键词：
Phage Clone; Tammar Wallaby; Pseudoautosomal Region; Autosomal Region; Pseudoautosomal Gene;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The X and Y Chromosomes (Chrs) of eutherian (“placental”) mammals share a pseudo-autosomal region (PAR) that pairs and recombines at meiosis. In humans and other eutherians, the PAR contains several active genes and has also been thought to be critical for pairing and fertility. In order to explore the origin of the PAR, we cloned and mapped three human or mouse pseudoautosomal genes in marsupials, a group of mammals that diverged from eutherians about 130 (MYrBP). All three genes were autosomal in marsupials, and two co-localized with other human Xp genes on an autosome. This implies that the human PAR, like most of human Xp, represents a relic of an autosomal region added to both X and Y Chrs between 80 and 150 MYrBP.
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页码：373 / 376
页数：3
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