Prognostic classification in acute exacerbation of idiopathic pulmonary fibrosis: a multicentre retrospective cohort study

被引:0
|
作者
Takahito Suzuki
Hironao Hozumi
Koichi Miyashita
Masato Kono
Yuzo Suzuki
Masato Karayama
Kazuki Furuhashi
Hirotsugu Hasegawa
Tomoyuki Fujisawa
Noriyuki Enomoto
Yutaro Nakamura
Naoki Inui
Koshi Yokomura
Hidenori Nakamura
Takafumi Suda
机构
[1] Hamamatsu University School of Medicine,Second Division, Department of Internal Medicine
[2] Seirei Hamamatsu General Hospital,Department of Respiratory Medicine
[3] Seirei Mikatahara General Hospital,Department of Respiratory Medicine
[4] Hamamatsu University School of Medicine,Department of Clinical Pharmacology and Therapeutics
来源
Scientific Reports | / 11卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Acute exacerbation (AE) in idiopathic pulmonary fibrosis (IPF) is a major prognostic determinant. However, evidence for its prognostic strength is mainly based on the results of small cohort studies with statistical limitations. This retrospective study, which included 108 patients with a first episode of AE-IPF, aimed to identify prognostic factors and to develop prognostic classification models. Multivariate Cox regression analysis revealed that a lower percent-predicted forced vital capacity within 12 months before AE onset (baseline %FVC) and a lower PaO2/FiO2 ratio at AE onset were independent mortality predictors. If the value of each predictor was lower than the cutoff determined by receiver-operating characteristic analysis, 1 point was assigned. Classification of patients into mild, moderate, and severe groups based on total score showed post-AE 90-day cumulative survival rates of 83.3%, 66.2%, and 22.2%, respectively (model 1: C-index 0.702). Moreover, a decision tree-based model was created with the recursive partitioning method using baseline %FVC and PaO2/FiO2 ratio at AE onset from among multivariable; accordingly, patients were classified into 3 groups with post-AE 90-day cumulative survival rates of 84.1%, 64.3%, and 24.0%, respectively (model 2: C-index 0.735). These models can guide clinicians in determining therapeutic strategies and help design future studies on AE-IPF.
引用
收藏
相关论文
共 50 条
  • [41] Serum Decorin As A Possible Prognostic Biomarker In Patients With Acute Exacerbation Of Idiopathic Pulmonary Fibrosis
    Nikaido, T.
    Tanino, Y.
    Fukuhara, N.
    Misa, K.
    Sato, Y.
    Togawa, R.
    Suzuki, Y.
    Uematsu, M.
    Fukuhara, A.
    Sato, S.
    Saito, J.
    Wang, X.
    Munakata, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [42] Serum decorin is a potential prognostic biomarker in patients with acute exacerbation of idiopathic pulmonary fibrosis
    Nikaido, Takefumi
    Tanino, Yoshinori
    Wang, Xintao
    Sato, Yuki
    Togawa, Ryuichi
    Kikuchi, Masami
    Misa, Kenichi
    Saito, Kazue
    Fukuhara, Naoko
    Kawamata, Takaya
    Rikimaru, Mami
    Umeda, Takashi
    Morimoto, Julia
    Koizumi, Tatsuhiko
    Suzuki, Yasuhito
    Hirai, Kenichiro
    Uematsu, Manabu
    Minemura, Hiroyuki
    Fukuhara, Atsuro
    Sato, Suguru
    Saito, Junpei
    Yokouchi, Hiroshi
    Kanazawa, Kenya
    Shibata, Yoko
    JOURNAL OF THORACIC DISEASE, 2018, 10 (09) : 5346 - 5358
  • [43] Preclinical idiopathic pulmonary fibrosis (IPF): a retrospective cohort study
    Bando, Tomohiro
    Takei, Reoto
    Fukihara, Jun
    Sasano, Hajime
    Yamano, Yasuhiko
    Yokoyama, Toshiki
    Matsuda, Toshiaki
    Kataoka, Kensuke
    Kimura, Tomoki
    Hatabu, Hiroto
    Fukuoka, Junya
    Johkoh, Takeshi
    Kondoh, Yasuhiro
    EUROPEAN RESPIRATORY JOURNAL, 2023, 62
  • [44] Hospital-level variation in practices and outcomes for patients with severe acute exacerbations of idiopathic pulmonary fibrosis: a retrospective multicentre cohort study
    Shankar, Divya A.
    Walkey, Allan J.
    Hawkins, Finn J.
    Bosch, Nicholas A.
    Peterson, Daniel
    Law, Anica C.
    BMJ OPEN RESPIRATORY RESEARCH, 2023, 10 (01)
  • [45] Recombinant Thrombomodulin In Acute Exacerbation Of Idiopathic Pulmonary Fibrosis
    Kondoh, Y.
    Taniguchi, H.
    Kimura, T.
    Kataoka, K.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [46] The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
    Weng, Dong
    Chen, Xian-Qiu
    Qiu, Hui
    Zhang, Yuan
    Li, Qiu-Hong
    Zhao, Meng-Meng
    Wu, Qin
    Chen, Tao
    Hu, Yang
    Wang, Liu-Sheng
    Wei, Ya-Ru
    Du, Yu-Kui
    Chen, Shan-Shan
    Zhou, Ying
    Zhang, Fen
    Shen, Li
    Su, Yi-Liang
    Kolb, Martin
    Li, Hui-Ping
    MEDIATORS OF INFLAMMATION, 2019, 2019
  • [47] Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis
    Kakugawa, Tomoyuki
    Sakamoto, Noriho
    Sato, Shuntaro
    Yura, Hirokazu
    Harada, Tatsuhiko
    Nakashima, Shota
    Hara, Atsuko
    Oda, Keishi
    Ishimoto, Hiroshi
    Yatera, Kazuhiro
    Ishimatsu, Yuji
    Obase, Yasushi
    Kohno, Shigeru
    Mukae, Hiroshi
    RESPIRATORY RESEARCH, 2016, 17
  • [48] Staging of Acute Exacerbation in Patients with Idiopathic Pulmonary Fibrosis
    Kishaba, Tomoo
    Tamaki, Hitoshi
    Shimaoka, Yousuke
    Fukuyama, Hajime
    Yamashiro, Shin
    LUNG, 2014, 192 (01) : 141 - 149
  • [49] The role of infection in acute exacerbation of Idiopathic Pulmonary Fibrosis
    Weng, Dong
    Li, Huiping
    EUROPEAN RESPIRATORY JOURNAL, 2018, 52
  • [50] The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
    Weng, D.
    Li, H.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199