Future directions in the prevention of prostate cancer

被引：0
作者：
Ian M. Thompson
April B. Cabang
Michael J. Wargovich
机构：
[1] Cancer Therapy and Research Center,
[2] University of Texas Health Science Center at San Antonio,undefined
来源：
Nature Reviews Clinical Oncology | 2014年 / 11卷
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摘要：
Chemoprevention has been increasingly explored to mitigate the global burden of prostate cancer and the overtreatment of indolent disease that has arisen in the prostate-specific antigen (PSA) screening eraPreclinical and epidemiological evidence suggested that selenium and α-tocopherol (vitamin E) might reduce the risk of prostate cancerA large trial found vitamin E to significantly increase the risk of prostate cancer and selenium to have no effect on riskThe strongest evidence supports the use of 5α-reductase inhibitors for prostate cancer prevention, with recent data showing that the risk reduction with these agents is 30%
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页码：49 / 60
页数：11
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