A case of rapidly progressing prostate cancer diagnosed 20 months after holmium laser enucleation of the prostate

被引:0
作者
Kazutaka Kida
Yousuke Shimizu
Kosuke Ogawa
Masahiro Emura
Sojun Kanamaru
Noriyuki Ito
机构
[1] Kobe City Nishi-Kobe Medical Center,Department of Urology
关键词
Prostate cancer; Holmium laser enucleation of the prostate;
D O I
10.1007/s13691-018-0324-3
中图分类号
学科分类号
摘要
A 65-year-old man presented for treatment of benign prostatic hyperplasia. His prostate volume was 50 cm3 and serum prostate-specific antigen was 1.93 ng/mL. Digital rectal examination showed no malignant nodules on the surface of the prostate. Holmium laser enucleation of the prostate was performed. The enucleated tissue was 21 g and pathological examination revealed no malignancy. Serum prostate-specific antigen had increased continuously to 6.38 ng/mL and prostate biopsy was performed 20 months after holmium laser enucleation of the prostate. Pathological examination confirmed an adenocarcinoma of the prostate with a Gleason score of 9 (4 + 5). Computed tomography and bone scintigraphy demonstrated multiple bone metastases and we made a diagnosis of prostate cancer, cT2aN0M1b. After 3 months on androgen deprivation therapy, he developed castration-resistant prostate cancer and died within 13 months after diagnosis of prostate cancer, despite receiving sequential therapy including enzalutamide, docetaxel and abiraterone. In our case, prostate-specific antigen was not measured until 13 months after holmium laser enucleation of the prostate, after which prostate-specific antigen rose from 1.93 to 4.09 ng/mL. This report provides an important implication of continuous monitoring of prostate-specific antigen after holmium laser enucleation of the prostate to detect prostate cancer early.
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页码:81 / 83
页数:2
相关论文
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