Time-of-day dependent pharmacodynamic and pharmacokinetic profiles of caffeine in rats

被引：0
|
作者：
Anne-Laure Pelissier-Alicot
Elisabeth Schreiber-Deturmeny
Nicolas Simon
Manon Gantenbein
Bernard Bruguerolle
机构：
[1] Laboratoire de Pharmacologie Médicale et Clinique,
[2] Faculté de Médecine,undefined
[3] Université de la Méditerranée,undefined
[4] 27 Bd. Jean Moulin,undefined
[5] 13385 Marseille Cedex 5,undefined
[6] France,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2002年 / 365卷
关键词：
Daily rhythms Telemetry Chronopharmacodynamics Chronopharmacokinetics Rats;
D O I：
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中图分类号：
学科分类号：
摘要：
This study aims to investigate the effects of caffeine on the daily rhythms of heart rate (HR), body temperature (BT) and locomotor activity (LA) in rats in relation to time-of-day of administration, as well as their possible mechanisms, particularly related to caffeine pharmacokinetics.
引用
收藏
页码：318 / 325
页数：7
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