Stroke risk in an elderly population with atrial fibrillation

被引:0
作者
William M. Feinberg
Richard A. Kronmal
Anne B. Newman
Michael A. Kraut
Edwin G. Bovill
Lawton Cooper
Robert G. Hart
机构
[1] University of Arizona Health Sciences Center,Received from the Department of Neurology
[2] University of Washington,Department of Biostatistics
[3] University of Pittsburgh,Department of Medicine, Division of Geriatric Medicine
[4] Johns Hopkins University,Department of Radiology
[5] University of Vermont,Department of Pathology
[6] National Institutes of Health,National Heart Lung and Blood Institute
[7] University of Texas Health Science Center,Department of Medicine, Neurology Division
来源
Journal of General Internal Medicine | 1999年 / 14卷
关键词
atrial fibrillation; aged; risk factors; stroke; cerebrovascular disease;
D O I
暂无
中图分类号
学科分类号
摘要
Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke, but the absolute rate of stroke varies widely depending on coexistent vascular disease. We assessed the stroke rate and predictive value of two published schemes for stroke risk stratification in a population-derived cohort of 259 elderly people with nonvalvular AF followed for a median of 5.3 years. The rate of ischemic stroke was 2.8% per year (95% confidence interval [CI] 1.9, 3.9). Thirty-one percent were predicted to be at low risk, and their stroke rate was 1.7% per year (95% CI 0.6, 3.8). Many people with AF in this population-derived cohort had relatively low rates of stroke. Further studies to reliably stratify stroke risk in patients with AF are needed.
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页码:56 / 59
页数:3
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[1]  
Wolf P(1991)Atrial fibrillation as an independent risk factor for stroke: the Framingham Study Stroke 22 983-8
[2]  
Abbott R(1987)The natural history of lone atrial fibrillation. A population-based study over three decades N Engl J Med 317 669-74
[3]  
Kannel W(1994)Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials Arch Intern Med 154 1449-57
[4]  
Kopecky S(1993)Secondary prevention in nonrheumatic atrial fibrillation after transient ischemic attack or minor stroke Lancet 342 1255-62
[5]  
Gersh B(1996)Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomized clinical trial Lancet 348 833-8
[6]  
McGoon M(1998)Patients with nonvalvular atrial fibrillation at low risk of stroke during treatment with aspirin: Stroke Prevention in Atrial Fibrillation III Study JAMA 279 1273-7
[7]  
Feinberg W(1995)Prevalence, age distribution, and gender of patients with atrial fibrillation: analysis and implications Arch Intern Med 155 469-73
[8]  
Blackshear J(1991)The Cardiovascular Health Study: design and rationale Ann Epidemiol 1 236-76
[9]  
Laupacis A(1993)Recruitment of adults 65 years and older as participants in the Cardiovascular Health Study Ann Epidemiol 3 358-66
[10]  
Kronmal R(1995)Antithrombotic therapy for atrial fibrillation Chest 108 S352-9