Design, Synthesis, and Biological Evaluation of Spider Toxin (Argiotoxin-636) Analogs as NMDA Receptor Antagonists

被引：0
|
作者：
Scott T. Moe
Daryl L. Smith
Yongwei (Eric) Chien
Joanna L. Raszkiewicz
Linda D. Artman
Alan L. Mueller
机构：
[1] Pharmacology Groups NPS Pharmaceuticals,Medicinal Chemistry and
[2] Inc.,Pharmacology Groups
[3] NPS Pharmaceuticals,undefined
[4] Inc.,undefined
来源：
Pharmaceutical Research | 1998年 / 15卷
关键词：
glutamate; NMDA; -methyl-D-aspartate; Argiotoxin-636; Arg-636; polyamine spider toxins; Araxin; compounds; ischemic stroke;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Twelve synthetic spider toxin analogs were prepared in an effort to better understand the structure-activity relationships of the polyamine portion of argiotoxin-636 (Arg-636), a noncompetitive NMDA receptor (NMDAR) antagonist.
引用
收藏
页码：31 / 38
页数：7
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