Regulation of microRNA expression and function by nuclear receptor signaling

被引：0
作者：
Zhihong Yang
Li Wang
机构：
[1] Huntsman Cancer Institute,Departments of Medicine and Oncological Sciences
[2] University of Utah School of Medicine,undefined
来源：
Cell & Bioscience | / 1卷
关键词：
miRNAs; nuclear receptors; gene regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNAs (miRNAs) are small non-coding RNA transcripts that affect various cellular pathways by serving as regulators of gene expression at the translational and transcriptional level. Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene transcription by binding to the promoter region or by interacting with other transcription factors. NRs can regulate miRNA expression either at the transcriptional level, or through posttranscriptional maturation by interacting with miRNA processing factors. This review will summarize recent advances in knowledge of the modulation of miRNA expression by NRs. Increased understanding of the molecular basis of miRNA expression may enable new therapeutic interventions that modulate miRNA activities through NR-mediated signaling.
引用
收藏
相关论文
共 815 条
  • [11] Hatzigeorgiou AG(2006)Genomics of microRNA Trends Genet 22 165-173
  • [12] Krol J(2008)Small non-coding RNAs in animal development Nat Rev Mol Cell Biol 9 219-230
  • [13] Loedige I(2009)Independent transcription of miR-281 in the intron of ODA in Drosophila melanogaster Biochem Biophys Res Commun 378 883-889
  • [14] Filipowicz W(2007)Mammalian mirtron genes Mol Cell 28 328-336
  • [15] Davis BN(2007)The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila Cell 130 89-100
  • [16] Hata A(2007)Intronic microRNA precursors that bypass Drosha processing Nature 448 83-86
  • [17] Breving K(2011)MicroRNA regulation of core apoptosis pathways in cancer Eur J Cancer 47 163-174
  • [18] Esquela-Kerscher A(2010)Targeting microRNAs in cancer: rationale, strategies and challenges Nat Rev Drug Discov 9 775-789
  • [19] Ozsolak F(2009)MicroRNAs: target recognition and regulatory functions Cell 136 215-233
  • [20] Poling LL(2008)Control of protein synthesis and mRNA degradation by microRNAs Curr Opin Cell Biol 20 214-221
12345678910