Synthesis and potential anticonvulsant activity of new aryl sulfonyl semicarbazide derivatives

被引：0
|
作者：
Yousong Nie
Min Zhong
Zhiyuan Jiang
Jian Sun
Yangguang Gao
Fei Ding
Hang Li
Yongmin Zhang
Xianran He
机构：
[1] Jianghan University,Institute for Interdisciplinary Research
[2] Jianghan University,Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, School of Chemical and Environmental Engineering
[3] Université Pierre et Marie Curie-Paris 6,Institut Parisien de Chimie Moléculaire, CNRS UMR 7201
来源：
Medicinal Chemistry Research | 2016年 / 25卷
关键词：
Aryl sulfonyl semicarbazide; MES; PTZ; Neurotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the present study on the development of new anticonvulsants, twelve new aryl sulfonyl semicarbazide derivatives were synthesized and tested for anticonvulsant activity using maximal electroshock (MES), subcutaneous pentylenetetrazole screens. Their neurotoxicity was determined by the rotorod test. The most active compound 5i showed the MES-induced seizures with ED50 value of 7.3 mg/kg and TD50 value of 402.3 mg/kg after intraperitoneally injection to mice, which provided compound 5i with a protective index (TD50/ED50) of 55.1 in the MES test.
引用
收藏
页码：1425 / 1432
页数：7
相关论文
共 50 条
  • [1] Synthesis and potential anticonvulsant activity of new aryl sulfonyl semicarbazide derivatives
    Nie, Yousong
    Zhong, Min
    Jiang, Zhiyuan
    Sun, Jian
    Guo, Yangguang
    Ding, Fei
    Li, Hang
    Zhang, Yongmin
    He, Xianran
    MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (07) : 1425 - 1432
  • [2] Synthesis and anticonvulsant activity of new phenytoin derivatives
    Botros, S.
    Khalil, Nadia A.
    Naguib, Bassem H.
    El-Dash, Yara
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 60 : 57 - 63
  • [3] Synthesis and potential anticonvulsant activity of new 5,5-cyclopropanespirohydantoin derivatives
    Nie, Yousong
    Zhong, Min
    Gao, Yangguang
    Ding, Fei
    Li, Hang
    Zhang, Yongmin
    He, Xianran
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (12) : 4207 - 4216
  • [4] Synthesis and potential anticonvulsant activity of new 5,5-cyclopropanespirohydantoin derivatives
    Yousong Nie
    Min Zhong
    Yangguang Gao
    Fei Ding
    Hang Li
    Yongmin Zhang
    Xianran He
    Medicinal Chemistry Research, 2015, 24 : 4207 - 4216
  • [5] Synthesis of some new thiadiazole derivatives and their anticonvulsant activity
    Rahman, M. A.
    Shakya, A. K.
    Wahab, S.
    Ansari, N. H.
    BULGARIAN CHEMICAL COMMUNICATIONS, 2014, 46 (04): : 750 - 756
  • [6] SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 4-ARYL-4-IMIDAZOLINE-2-ONE DERIVATIVES
    CALIS, U
    DALKARA, S
    ERTAN, M
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1992, 42-1 (05): : 592 - 594
  • [7] Synthesis and anticonvulsant activity of new kojic acid derivatives
    Aytemir, Mutlu Dilsiz
    Septioglu, Ebubekir
    Calis, Uensal
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2010, 60 (01): : 22 - 29
  • [8] Synthesis and anticonvulsant activity of some new dioxolane derivatives
    Özkanli, F
    Güney, A
    Çalis, Ü
    Uzbay, T
    ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2003, 53 (11): : 758 - 762
  • [9] Synthesis of aryl semicarbazones as potential anticonvulsant agents
    Yogeeswari, P
    Sriram, D
    Veena, V
    Kavya, R
    Rakhra, K
    Ragavendran, JV
    Mehta, S
    Thirumurugan, R
    Stables, JP
    BIOMEDICINE & PHARMACOTHERAPY, 2005, 59 (1-2) : 51 - 55
  • [10] Synthesis and analgesic activity of some new phenyl sulfonyl derivatives
    Gupta, Sumit
    Pandeya, Surendpa N.
    Kumar, Praveen
    Tripathi, Laxmi
    ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (04) : 2818 - 2822
12345