Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population

被引：0
作者：
AsmaGul Naz
Muhammad Assad Aslam
Abrar Ul Haq Khan
Sumaira Rasul
Hamid Manzoor
Rehana Iqbal
Ahmed Shehzad
Muhammad Ali
机构：
[1] Bahauddin Zakariya University,Institute of Molecular Biology and Biotechnology
[2] University of Agriculture Faisalabad,Institute of Microbiology
[3] Bahauddin Zakariya University,Institute of Pure and Applied Biology
[4] Bahauddin Zakariya University,Department of Statistics
[5] Government College University Faisalabad,undefined
来源：
Brazilian Journal of Microbiology | 2019年 / 50卷
关键词：
Tuberculosis; Polymorphism; (rs4740) ; Smoking;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tuberculosis is becoming a global issue with raising occurrences; particularly in developing countries, the situation is alarming. Besides environmental factors, host genetic factors are vital in disease development. A demographical and genotypic analysis in relation to tuberculosis commencement is conducted in a Pakistani population, and genotypic frequency of EBI3 (rs4740) was analyzed. Allelic frequencies of EBI3 (rs4740) were significantly associated with disease susceptibility in the reviewed population. Analysis for EBI3 (rs4740) genotyping showed a significant association of “GG” with reduced risk for disease. Moreover, females and older age found to be more perilous to develop TB while smoking and a family history of TB are additional risk factors for disease development. Further work with a larger population is necessary to identify the true causative variants of tuberculosis.
引用
收藏
页码：429 / 434
页数：5
相关论文
共 232 条
  • [1] Hu Q(2016)Association of genetic polymorphisms with pulmonary tuberculosis in a Chinese Tibetan population: a case-control study Int J Clin Exp Pathol 9 267-274
  • [2] Schluger NW(2001)Recent advances in our understanding of human host responses to tuberculosis Respir Res 2 157-163
  • [3] Zumla A(2013)WHO’s 2013 global report on tuberculosis: successes, threats, and opportunities Lancet 382 1765-1767
  • [4] George A(2004)Single Nucleotide Polymorphisms (SNPs) of the TNF-alpha (-238/-308) gene among TB and nom TB patients: susceptibility markers of TB occurrence? J Bras Pneumol 30 371-377
  • [5] Sharma V(2009)Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-γ genes and its association with susceptibility to tuberculosis Braz J Med Biol Res 42 312-322
  • [6] Herbert N(2006)The resumption of consumption: a review on tuberculosis Mem Inst Oswaldo Cruz 101 697-714
  • [7] Oliveira MMd(2012)Innate immune gene polymorphisms in tuberculosis Infect Immun 80 3343-3359
  • [8] Leandro A(2014)MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection Eur J Immunol 44 1399-1409
  • [9] Rocha M(2015)Epstein–Barr virus-induced gene 3 (EBI3) polymorphisms and expression are associated with susceptibility to pulmonary tuberculosis Tuberculosis 95 497-504
  • [10] Cardoso C(2002)IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells Immunity 16 779-790
12345678910