Efficacy of prophylactic dexamethasone in prevention of postoperative nausea and vomiting

被引：13

作者：

Sekhavat L. ^{[1
]}

Davar R. ^{[2
]}

Behdad S. ^{[3
]}

机构：

[1] Department of Obstetrics and Gynecologist, Shahid Sadoughi University of Medical Sciences, Yazd

[2] Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd

[3] Department of Anesthesia, Shahid Sadoughi University of Medical Sciences, Yazd

来源：

Journal of Epidemiology and Global Health | 2015年 / 5卷 / 2期

关键词：

Dexamethasone; Nausea and vomiting; Postoperative; Rescue anti-emetic;

D O I：

10.1016/j.jegh.2014.07.004

中图分类号：

学科分类号：

摘要：

Objective: Many trials have been conducted with regard to the relative benefits of prophylactic anti-emetic interventions given alone or in combination, yet the results remain unknown. This study reviewed the efficacy of a single prophylactic dose of dexamethasone on postoperative nausea or vomiting (PONV) after abdominal hysterectomy. Methods: In a prospective study of 100 women undergoing total abdominal hysterectomy (TAH) under general anesthesia, the dexamethasone group (. n=. 50) received a single dose (8. mg) immediately after the operation, and the saline group (. n=. 50) received a dose of saline as a placebo, in addition to conventional management. The incidence of nausea, vomiting, the need for an anti-emetic and patient satisfaction with the management of PONV were evaluated during the first 24 postoperative hours. Results: The overall frequency of nausea during the initial postoperative 24 in the dexamethasone and saline groups were 12% and 18%, respectively, and vomiting was 10% and 16%, respectively (P=0.001). However, there was a lower need for a rescue anti-emetic drugs in the dexamethasone group (18% vs 24%), but it was not statistically significant (P=0.06). Conclusion: The results of this study indicate that a single prophylactic dose of dexamethasone after an operation can reduce postoperative nausea and vomiting. © 2014 Ministry of Health, Saudi Arabia.

引用

页码：175 / 179

页数：4

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