Localization of monoamine oxidase A and B and semicarbazide-sensitive amine oxidase in human peripheral tissues

被引：12
|
作者：
D. Ramonet
M. Rodríguez
J. Saura
J. M. Lizcano
M. Romera
M. Unzeta
C. Finch
E. Billett
N. Mahy
机构：
来源：
InflammoPharmacology | 2003年 / 11卷 / 2期
关键词：
IMMUNOHISTOCHEMISTRY; SEMICARBAZIDE; MONOAMINE OXIDASES; HUMAN.;
D O I：
10.1163/156856003765764272
中图分类号：
学科分类号：
摘要：
Monoamine oxidase (MAO) A and B and semicarbazide-sensitive amine oxidase (SSAO) localizations in peripheral human tissues were compared by immunohistochemistry. The primary antibodies used were mouse monoclonal anti-human MAO-A (6G11/E1) and anti-human MAO-B (3F12/G10/2E3) and a rabbit polyclonal anti-bovine SSAO antibody. Immunoreactivities of the samples, obtained from 6 routine autopsy cases, showed different distributions in the tissues studied (heart, lung, duodenum, liver, pancreas, spleen, thyroid gland, adrenal gland and kidney). The relative MAO-A, MAO-B and SSAO distributions indicated a widespread distribution of these enzymes in the human body that is characterized by a matching cellular pattern in only few tissues. These differences suggest that each amine oxidase may play a specific function in, at least some, peripheral tissues.
引用
收藏
页码：111 / 117
页数：6
相关论文
共 50 条
  • [41] Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat
    Claud, P
    Padovani, P
    Guichard, JP
    Artur, Y
    Lainé, R
    DRUG METABOLISM AND DISPOSITION, 2001, 29 (05) : 735 - 741
  • [42] The role of “semicarbazide-sensitive amine oxidase” in the arterial wall
    N. Mercier
    Artery Research, 2009, 3 (4) : 141 - 147
  • [43] Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase Kinetic Analysis in Mesenteric Arteries of Patients With Type 2 Diabetes
    Nunes, S. F.
    Figueiredo, I. V.
    Pereira, J. S.
    de Lemos, E. T.
    Reis, F.
    Teixeira, F.
    Caramona, M. M.
    PHYSIOLOGICAL RESEARCH, 2011, 60 (02) : 309 - 315
  • [44] THE DEAMINATION OF NORMAL-PENTYLAMINE BY MONOAMINE-OXIDASE AND A SEMICARBAZIDE-SENSITIVE AMINE OXIDASE OF RAT-HEART
    GUFFROY, C
    FOWLER, CJ
    BENEDETTI, MS
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (07) : 416 - 420
  • [45] In vitro metabolism of tresperimus by human vascular semicarbazide-sensitive amine oxidase
    Claud, P
    Artur, Y
    Laine, R
    DRUG METABOLISM AND DISPOSITION, 2002, 30 (06) : 747 - 755
  • [46] Semicarbazide-sensitive amine oxidase (SSAO): present and future
    Kálmán Magyar
    Zsuzsa Mészáros
    InflammoPharmacology, 2003, 11 (2) : 165 - 173
  • [47] Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors
    Carpene, C.
    Abello, V.
    Iffiu-Soltesz, Z.
    Mercier, N.
    Feve, Bruno
    Valet, P.
    PHARMACOLOGICAL RESEARCH, 2008, 57 (06) : 426 - 434
  • [48] INHIBITION OF MONOAMINE OXIDASE-A-FORM AND SEMICARBAZIDE-SENSITIVE AMINE OXIDASE BY SELECTIVE AND REVERSIBLE MONOAMINE OXIDASE-A INHIBITORS, AMIFLAMINE AND FLA-788(+)
    MORIKAWA, F
    UEDA, T
    ARAI, Y
    KINEMUCHI, H
    PHARMACOLOGY, 1986, 32 (01) : 38 - 45
  • [49] Enzymatic activities of monoamine oxidase (type A and B) and semicarbazide-sensitive amine oxidase (SSAO) in colonic arteries of type 2 diabetic patients
    Nunes, S. F.
    Figueiredo, I. V.
    Pereira, J. S.
    Lemos, E. T.
    Baptista, S.
    Teixeira, F.
    Caramona, M. M.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 : 101 - 101
  • [50] SEMICARBAZIDE-SENSITIVE AMINE OXIDASE AND MONOAMINE-OXIDASE IN RAT-BRAIN MICROVESSELS, MENINGES, RETINA AND EYE SCLERA
    ZUO, DM
    YU, PH
    BRAIN RESEARCH BULLETIN, 1994, 33 (03) : 307 - 311
12345