Role of myocardial 123I-mIBG innervation imaging in the diagnosis of neurodegenerative diseases

被引：0
作者：
Albert Flotats
机构：
[1] Universitat Autònoma de Barcelona,Nuclear Medicine Department
[2] Hospital de la Santa Creu i Sant Pau,undefined
来源：
Clinical and Translational Imaging | 2018年 / 6卷
关键词：
I-mIBG; Myocardial innervation; Neurodegenerative diseases; Parkinsonisms; Alzheimer's disease; Differential diagnosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neurodegenerative diseases occur when neurons in the central and/or peripheral nervous systems lose function over time and ultimately die. They are characterized by common cellular and molecular mechanisms including protein aggregation and inclusion body formation, categorising each type of disease. Therefore, the definitive diagnosis is at post-mortem, based on pathology. However, the development of various molecular imaging techniques has enabled pathological changes to be inferred in vivo. Decreased myocardial 123I-mIBG uptake has been reported in some patients with neurodegenerative diseases. This review is aimed to synthesise the basis, methodology and clinical role of myocardial 123I-mIBG imaging in the diagnosis of certain neurodegenerative diseases, focusing on its utility to differentiate some neurodegenerative Parkinsonisms between them, and to differentiate dementia with Lewy bodies from Alzheimer’s disease and other dementias.
引用
收藏
页码：449 / 458
页数：9
相关论文
共 312 条
  • [31] Mizusawa H(2011)Optimizing Parkinson’s disease diagnosis: the role of a dual nuclear imaging algorithm Clin Neurol Neurosurg 113 823-55
  • [32] Wakabayashi T(2012)The role of cardiac metaiodobenzylguanidine uptake in the differential diagnosis of parkinsonian syndromes Clin Auton Res 22 43-500
  • [33] Nakata T(2012)Diagnostic performance of iodine-123-metaiodobenzylguanidine scintigraphy in differential diagnosis between Parkinson’s disease and multiple-system atrophy: a systematic review and a meta-analysis Parkinsonism Relat Disord 18 494-426
  • [34] Hashimoto A(2003)MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis J Neurol Neurosurg Psychiatry 74 423-375
  • [35] Yuda S(1999)123I-MIBG myocardial scintigraphy for differentiating Parkinson’s disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis J Nucl Med 40 371-288
  • [36] Tsuchihashi K(2006)Onset age and severity of motor impairment are associated with reduction of myocardial 123I-MIBG uptake in Parkinson’s disease Parkinsonism Relat Disord 12 284-353
  • [37] Travin MI(2014)Loss of 123I-MIBG uptake by the heart in Parkinson’s disease: assessment of cardiac sympathetic denervation and diagnostic value Acta Neurol Scan 130 347-111
  • [38] Somsen GA(2004)Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson’s disease correlate with major autonomic symptoms? J Neurol Sci 220 105-1342
  • [39] Verberne HJ(2012)Relationship and factor structure in multisystem neurodegeneration in Parkinson’s disease Mol Med Rep 6 1337-375
  • [40] Fleury E(2011)Cardiac 123I-MIBG scintigraphy can assess the disease severity and phenotype of PD Parkinsonism Relat Disord 17 372-925
12345678910