Role of myocardial 123I-mIBG innervation imaging in the diagnosis of neurodegenerative diseases

被引：0
作者：
Albert Flotats
机构：
[1] Universitat Autònoma de Barcelona,Nuclear Medicine Department
[2] Hospital de la Santa Creu i Sant Pau,undefined
来源：
Clinical and Translational Imaging | 2018年 / 6卷
关键词：
I-mIBG; Myocardial innervation; Neurodegenerative diseases; Parkinsonisms; Alzheimer's disease; Differential diagnosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neurodegenerative diseases occur when neurons in the central and/or peripheral nervous systems lose function over time and ultimately die. They are characterized by common cellular and molecular mechanisms including protein aggregation and inclusion body formation, categorising each type of disease. Therefore, the definitive diagnosis is at post-mortem, based on pathology. However, the development of various molecular imaging techniques has enabled pathological changes to be inferred in vivo. Decreased myocardial 123I-mIBG uptake has been reported in some patients with neurodegenerative diseases. This review is aimed to synthesise the basis, methodology and clinical role of myocardial 123I-mIBG imaging in the diagnosis of certain neurodegenerative diseases, focusing on its utility to differentiate some neurodegenerative Parkinsonisms between them, and to differentiate dementia with Lewy bodies from Alzheimer’s disease and other dementias.
引用
收藏
页码：449 / 458
页数：9
相关论文
共 312 条
[11]  
Ferman TJ(2004)Normal values and within subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies J Nucl Cardiol 11 126-133
[12]  
Boeve BF(2014)Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations J Nucl Cardiol 21 970-978
[13]  
Zaccai J(2018)A European myocardial 123I-mIBG cross-calibration phantom study J Nucl Cardiol 25 1191-1197
[14]  
McCracken C(2017)Standardization of Clin Transl Imaging 5 255-263
[15]  
Brayne C(2013)I- Handb Clin Neurol 117 365-370
[16]  
Shapiro B(1997)-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications Eur Neurol 38 2-7
[17]  
Gross MD(2013)Sympathetic neuroimaging Handb Clin Neurol 117 45-57
[18]  
Jacobson AF(2018)Neuropathology of autonomic nervous system in Parkinson’s disease Eur J Nucl Med Mol Imaging 45 1534-1545
[19]  
Travin MI(2015)Central control of autonomic function and involvement in neurodegenerative disorders Mov Disord 30 1591-1601
[20]  
Flotats A(2006)Clinical utility of FDG PET in Parkinson’s disease and atypical parkinsonism associated with dementia J Nucl Med 47 1099-1101
12345678910