Role of myocardial 123I-mIBG innervation imaging in the diagnosis of neurodegenerative diseases

被引:0
作者
Albert Flotats
机构
[1] Universitat Autònoma de Barcelona,Nuclear Medicine Department
[2] Hospital de la Santa Creu i Sant Pau,undefined
来源
Clinical and Translational Imaging | 2018年 / 6卷
关键词
I-mIBG; Myocardial innervation; Neurodegenerative diseases; Parkinsonisms; Alzheimer's disease; Differential diagnosis;
D O I
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学科分类号
摘要
Neurodegenerative diseases occur when neurons in the central and/or peripheral nervous systems lose function over time and ultimately die. They are characterized by common cellular and molecular mechanisms including protein aggregation and inclusion body formation, categorising each type of disease. Therefore, the definitive diagnosis is at post-mortem, based on pathology. However, the development of various molecular imaging techniques has enabled pathological changes to be inferred in vivo. Decreased myocardial 123I-mIBG uptake has been reported in some patients with neurodegenerative diseases. This review is aimed to synthesise the basis, methodology and clinical role of myocardial 123I-mIBG imaging in the diagnosis of certain neurodegenerative diseases, focusing on its utility to differentiate some neurodegenerative Parkinsonisms between them, and to differentiate dementia with Lewy bodies from Alzheimer’s disease and other dementias.
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页码:449 / 458
页数:9
相关论文
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  • [1] Elbaz A(2016)Epidemiology of Parkinson’s disease Rev Neurol (Paris) 172 14-26
  • [2] Carcaillon L(2004)Dementia with Lewy bodies Lancet Neurol 3 19-28
  • [3] Kab S(2007)Dementia with Lewy bodies Neurol Clin 25 741-747
  • [4] Moisan F(2005)A systematic review of prevalence and incidence studies of dementia with Lewy bodies Age Ageing 34 561-566
  • [5] McKeith I(1987)Radiochemistry, biochemistry, and kinetics of 131I-metaiodobenzylguanidine (MIBG) and 123I-MIBG: clinical implications of the use of 123I-MIBG Med Pediatric Oncol 15 170-177
  • [6] Mintzer J(2015)Impact of medications on mIBG uptake, with specific attention to the heart: comprehensive review of the literature J Nucl Cardiol 22 980-993
  • [7] Aarsland D(2010)Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology Eur J Nucl Med Mol Imaging 37 1802-1812
  • [8] Burn D(1998)Differentiation of idiopathic Parkinson’s disease from striatonigral degeneration and progressive supranuclear palsy using iodine-123 meta-iodobenzylguanidine myocardial scintigraphy J Neurol Sci 155 60-67
  • [9] Chiu H(1999)123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson’s disease J Neurol Neurosurg Psychiatry 67 189-194
  • [10] Cohen-Mansfield J(2001)Assessment of underlying etiology and cardiac sympathetic innervation to identify patients at high risk of cardiac events J Nucl Med 42 1757-1767