Determination of dopamine D2 receptor occupancy by lurasidone using positron emission tomography in healthy male subjects

被引:0
作者
Dean F. Wong
Hiroto Kuwabara
James Robert Brašić
Thomas Stock
Atul Maini
Emily G. Gean
Antony Loebel
机构
[1] Johns Hopkins Medical Institutions (JHMI),Department of Radiology
[2] PAREXEL International,undefined
[3] Harbor Hospital Center,undefined
[4] Sunovion Pharmaceuticals Inc,undefined
[5] Sunovion Pharmaceuticals Inc,undefined
来源
Psychopharmacology | 2013年 / 229卷
关键词
Positron emission tomography; Antipsychotic agents; Dopamine D; receptors; Lurasidone; Dose–response relationship; Drug;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:245 / 252
页数:7
相关论文
共 212 条
[1]  
Abanades S(2011)Prediction of repeat-dose occupancy from single-dose data: characterization of the relationship between plasma pharmacokinetics and brain target occupancy J Cereb Blood Flow Metab 31 944-952
[2]  
van der Aart J(1999)Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study J Neuropsychiatry Clin Neurosci 11 71-78
[3]  
Barletta JA(2011)Lurasidone for schizophrenia: a review of the efficacy and safety profile for this newly approved second-generation antipsychotic Int J Clin Pract 65 189-210
[4]  
Marzano C(1994)Performance characteristics of a whole-body PET scanner J Nuc Med 35 1398-1406
[5]  
Searle GE(2010)Focus on lurasidone: a new atypical antipsychotic for the treatment of schizophrenia Formulary 45 313-317
[6]  
Salinas CA(1985)Preparation of 11C-labelled Raclopride, a new potent dopamine receptor antagonist: preliminary PET studies of cerebral dopamine receptors in the monkey Int J Appl Radiat Isot 36 269-273
[7]  
Ahmad JJ(1995)Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients J Clin Psychopharmacol 15 19S-23S
[8]  
Reiley RR(2006)The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia Neuropsychopharmacol 31 1027-1035
[9]  
Pampols-Maso S(2002)Strategies to improve neuroreceptor parameter estimation by linear regression analysis J Cereb Blood Flow Metab 22 1271-1281
[10]  
Zamuner S(2007)Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 1533-1539