Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma

被引：0

作者：

Jeremy Clark

Yong-Jie Lu

Sanjiv K Sidhar

Chris Parker

Sandra Gill

Damian Smedley

Rifat Hamoudi

W Marston Linehan

Janet Shipley

Colin S Cooper

机构：

[1] Section of Molecular Carcinogenesis,

[2] Institute of Cancer Research,undefined

[3] Haddow Laboratories,undefined

[4] Belmont,undefined

[5] Section of Cell Biology and Experimental Pathology,undefined

[6] Institute of Cancer Research,undefined

[7] Haddow Laboratories,undefined

[8] Belmont,undefined

[9] Cancer Gene Cloning Laboratory,undefined

[10] Institute of Cancer Research,undefined

[11] Haddow Laboratories,undefined

[12] Belmont,undefined

[13] Urologic Oncology Section,undefined

[14] National Cancer Institute,undefined

来源：

Oncogene | 1997年 / 15卷

关键词：

renal cell carcinoma; PSF splicing factor; (; ) splicing factor; chromosome translocations; TFE3 transcription factor;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We demonstrate that the cytogenetically defined translocation t(X;1)(p11.2;p34) observed in papillary renal cell carcinomas results in the fusion of the splicing factor gene PSF located at 1p34 to the TFE3 helix – loop – helix transcription factor gene at Xp11.2. In addition we define an X chromosome inversion inv(X)(p11.2;q12) that results in the fusion of the NonO (p54nrb) gene to TFE3. NonO (p54nrb), the human homologue of the Drosophila gene NonAdiss which controls the male courtship song, is closely related to PSF and also believed to be involved in RNA splicing. In each case the rearrangement results in the fusion of almost the entire splicing factor protein to the TFE3 DNA-binding domain. These observations suggest the possibility of intriguing links between the processes of RNA splicing, DNA transcription and oncogenesis.

引用

页码：2233 / 2239

页数：6