Long Covid: where we stand and challenges ahead

被引：0
作者：
Alberto Mantovani
Maria Concetta Morrone
Carlo Patrono
M. Gabriella Santoro
Stefano Schiaffino
Giuseppe Remuzzi
Giovanni Bussolati
机构：
[1] IRCCS Humanitas Research Hospital,Department of Biomedical Sciences
[2] Humanitas University,Department of Translational Research on New Technologies in Medicine and Surgery
[3] William Harvey Research Institute,Department of Biology
[4] Queen Mary University,School of Medicine
[5] Scientific Institute Stella Maris (IRCSS),Department of Physics
[6] University of Pisa,School of Public Health
[7] Institute of Pharmacology,undefined
[8] Catholic University School of Medicine,undefined
[9] and Fondazione Policlinico Universitario “A. Gemelli” Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS),undefined
[10] University of Rome Tor Vergata,undefined
[11] Institute of Translational Pharmacology,undefined
[12] CNR,undefined
[13] Venetian Institute of Molecular Medicine,undefined
[14] University of Padua,undefined
[15] IRCCS Istituto di Ricerche Farmacologiche Mario Negri,undefined
[16] Accademia Nazionale dei Lincei,undefined
[17] University of Turin,undefined
[18] University of Sassari,undefined
[19] Institute for Translational Medicine and Therapeutics,undefined
[20] University of Pennsylvania,undefined
[21] University of Florence,undefined
[22] University of Rome “Tor Vergata”,undefined
[23] University of Rome ‘La Sapienza’’,undefined
[24] Head External R&D Division,undefined
[25] Glaxo Smith Kline Vaccines,undefined
[26] Vaccines Research,undefined
[27] Imperial College of London,undefined
[28] Istituto Superiore di Sanità,undefined
[29] Imperial College London,undefined
来源：
Cell Death & Differentiation | 2022年 / 29卷
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摘要：
Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially as Long Covid, has been defined as a constellation of signs and symptoms which persist for weeks or months after the initial SARS-CoV-2 infection. PASC affects a wide range of diverse organs and systems, with manifestations involving lungs, brain, the cardiovascular system and other organs such as kidney and the neuromuscular system. The pathogenesis of PASC is complex and multifactorial. Evidence suggests that seeding and persistence of SARS-CoV-2 in different organs, reactivation, and response to unrelated viruses such as EBV, autoimmunity, and uncontrolled inflammation are major drivers of PASC. The relative importance of pathogenetic pathways may differ in different tissue and organ contexts. Evidence suggests that vaccination, in addition to protecting against disease, reduces PASC after breakthrough infection although its actual impact remains to be defined. PASC represents a formidable challenge for health care systems and dissecting pathogenetic mechanisms may pave the way to targeted preventive and therapeutic approaches.
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页码：1891 / 1900
页数：9
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