Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis

被引：0

作者：

S G Schwab

G N Eckstein

J Hallmayer

B Lerer

M Albus

M Borrmann

D Lichtermann

M A Ertl

W Maier

D B Wildenauer

机构：

[1] University of Bonn,Department of Psychiatry

[2] Graylands Hospital/University of Western Australia,Department of Psychiatry

[3] Centre for Clinical Research in Neuropsychiatry,undefined

[4] Dept of Psychiatry,undefined

[5] Hadassah-Hebrew University Medical Center,undefined

[6] Mental State Hospital,undefined

[7] National Public Health Institute,undefined

[8] University of Munich,undefined

来源：

Molecular Psychiatry | 1997年 / 2卷

关键词：

lod score analysis; affected sib-pair analysis; schizophrenia; chromosome 5;

D O I：

暂无

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学科分类号：

摘要：

Suggestive evidence for a potential susceptibility locus for schizophrenia at 5q31 was obtained in two family samples. Sample I consisted of 14 families with schizophrenia and revealed for the marker IL9 a lod score of 1.8 by two point lod score analysis. Sample II comprised 44 families including four from sample I and was ascertained in order to employ affected sib-pair analysis by identity by descent. A lod score of 1.8 around the marker D5S399 was obtained by multipoint analysis. The lod score remained positive, but decreased to 1.27 when the four families from sample I were excluded in order to use sample II as a statistically independent replication sample. We propose a susceptibility locus for schizophrenia with probably minor contribution in the pedigrees under investigation.

引用

页码：156 / 160

页数：4