Glial fibrillary acidic protein (GFAP)-antibody in children with focal seizures of undetermined cause

被引：0

作者：

Merve Savaş

John Tzartos

Cem İsmail Küçükali

Erdinç Dursun

Katerina Karagiorgou

Duygu Gezen-Ak

Dilşad Türkdoğan

Aliki Papaconstantinou

Sezin Başoğlu

Nilüfer Hacıhafızoğlu

Büşra Kutlubay

Socrates Tzartos

Erdem Tüzün

机构：

[1] Biruni University,Department of Speech and Language Therapy, Faculty of Health Science

[2] Tzartos NeuroDiagnostics,1st Department of Neurology, Medical School

[3] Eginition Hospital,Department of Neuroscience

[4] University of Athens,Department of Medical Biology, Cerrahpasa Faculty of Medicine

[5] Aziz Sancar Institute for Experimental Medical Research,Division of Child Neurology, Department of Pediatrics, Faculty of Medicine

[6] Istanbul University,Department of Pediatrics

[7] Istanbul University-Cerrahpaşa,Department of Pediatrics

[8] Marmara University,undefined

[9] Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital,undefined

[10] Umraniye Training and Research Hospital,undefined

[11] Hellenic Pasteur Institute,undefined

来源：

Acta Neurologica Belgica | 2021年 / 121卷

关键词：

Glial fibrillary acidic protein; Epilepsy; Seizure; Antibody; Autoimmunity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Anti-neuronal antibodies that are related with autoimmune encephalitis syndromes may also be found in children with new onset seizures or chronic epilepsy. To unravel the significance of autoimmune astrocytopathy in epilepsy, we investigated serum antibody to glial fibrillary acidic protein (GFAP), another autoantigen described in autoimmune encephalitis with seizures, in 38 children with focal seizures of undetermined cause. GFAP antibody was screened with cell based assay and indirect immunohistochemistry and was found in two boys with normal brain MRI and unrevealing medical history prior to seizures. The 2-year-old boy had chronic treatment-resistant frontal lobe epilepsy. The 2.5-year-old boy had a single episode of focal seizures and remained seizure free thereafter in a follow-up period of 4 years. Nevertheless, he showed severe cognitive and language impairment. These results suggest that autoimmune astrocytopathy may be present in some epilepsy patients. Whether this immune response is a bystander effect generated by seizure-induced astrocytosis or directly involved in epileptogenesis needs to be further studied.

引用

页码：1275 / 1280

页数：5

共 195 条

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