Hypertensive Disorders of Pregnancy and Cardiovascular Diseases: Current Knowledge and Future Directions

被引：63
作者：
Coutinho T. [1 ,2 ,3 ]
Lamai O. [3 ]
Nerenberg K. [4 ]
机构：
[1] Canadian Women’s Heart Health Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, K1Y 4W7, ON
[2] Division of Cardiac Prevention & Rehabilitation, University of Ottawa Heart Institute, Ottawa, ON
[3] Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON
[4] Departments of Medicine, Obstetrics & Gynecology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB
来源：
Current Treatment Options in Cardiovascular Medicine | 2018年 / 20卷 / 7期
关键词：
Cardiovascular disease; Heart failure; Hypertensive disorders of pregnancy; Myocardial infarction; Preeclampsia; Stroke;
D O I：
10.1007/s11936-018-0653-8
中图分类号：
学科分类号：
摘要：
Purpose of the review: Cardiovascular diseases (CVDs) are the principal killers of women. In this review, we summarize data regarding CVD and mortality after hypertensive disorders of pregnancy (HDP), and highlight clinical, research and policy needs to mitigate this risk. Recent findings: Robust data indicate that women with HDP have substantially higher risk of future CVD, with a 3.7-fold increase in the risk of chronic hypertension, a 4.2-fold increase in the risk of heart failure, an 81% increase in the risk of stroke, and double the risk of atrial arrhythmias, coronary heart disease, and mortality when compared to women with normotensive pregnancies. Potential explanations include (1) the effect of pregnancy as a “stress test” in women destined to develop CVD, (2) mediation by conventional risk factors, (3) long-term vascular damage sustained during the preeclamptic episode, and (4) preexisting abnormalities in arterial health predisposing women to HDP, and, subsequently, CVD. Summary: Women with HDP have significantly increased risk of CVD and mortality. Risk scores including obstetric history are necessary to better estimate a woman’s cardiovascular risk. In addition, comprehensive policies promoting systematic risk assessment and modification after HDP are critically needed to improve health, wellness, and survival of affected women. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
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