Bone metabolism and new targets for intervention

被引：1
作者：
Akduman B. [1 ]
Crawford E.D. [1 ]
机构：
[1] Department of Urology, School of Medicine, Zonguldak Karaelmas University
来源：
Current Urology Reports | 2007年 / 8卷 / 3期
关键词：
Prostate Cancer; Vascular Endothelial Growth Factor; Docetaxel; Imatinib; Bone Metastasis;
D O I：
10.1007/s11934-007-0011-y
中图分类号：
学科分类号：
摘要：
Bone metastasis is a common complication of prostate cancer and is associated with significant morbidity for patients. Bone metabolism and prostate cancer metastasis to bone are complex processes. The interactions between host cells and metastatic prostate cancer cells are important components of organ-specific cancer progression. In addition to traditional treatment approaches, targeted therapy is currently becoming more popular. Bone metabolism, metastatic processes of prostate cancer, and the targeting of treatment for advanced disease are discussed here. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：233 / 238
页数：5
相关论文
共 63 条
  • [1] Rubin M.A., Putzi M., Mucci N., Et al., Rapid ("warm") autopsy study for procurement of metastatic prostate cancer, Clin Cancer Res, 6, pp. 1038-1045, (2000)
  • [2] Oades G.M., Coxon J., Colston K.W., The potential role of bisphosphonates in prostate cancer, Prostate Cancer Prostatic Dis, 5, pp. 264-272, (2002)
  • [3] Paget S., The distribution of growths in cancer of the breast, Lancet, I 571, (1889)
  • [4] Ewing J., A Treatise on Tumors, (1928)
  • [5] Fidler I.J., The organ microenvironment and cancer metastasis, Differentiation, 70, pp. 498-505, (2002)
  • [6] Bubendorf L., Schopfer A., Wagner U., Et al., Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients, Hum Pathol, 31, pp. 578-583, (2000)
  • [7] Kahn D., Weiner G.J., Ben-Haim S., Et al., Positron emission tomographic measurement of bone marrow blood flow to the pelvis and lumbar vertebrae in young normal adults, Blood, 83, pp. 958-963, (1994)
  • [8] van der Pluijm G., Sijmons B., Vloedgraven H., Et al., Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: Elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases, J Bone Miner Res, 16, pp. 1077-1091, (2001)
  • [9] Hauschka P.V., Mavrakos A.E., Iafrati M.D., Et al., Growth factors in bone matrix: Isolation of multiple types by affinity chromatography on heparin-sepharose, J Biol Chem, 261, pp. 12665-12674, (1986)
  • [10] Pfeilschifter J., Mundy G.R., Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones, Proc Natl Acad Sci USA, 84, pp. 2024-2028, (1987)
1234567