Insulators of higher eukaryotes: Properties, mechanisms of action, and role in transcriptional regulation

被引：0
|
作者：
O. G. Maksimenko
D. A. Chetverina
P. G. Georgiev
机构：
[1] Russian Academy of Sciences,Institute of Gene Biology
来源：
Russian Journal of Genetics | 2006年 / 42卷
关键词：
Differential Methylation Region; Nuclear Matrix Protein; Insulator Activity; Chromatin Insulator; Gypsy Insulator;
D O I：
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中图分类号：
学科分类号：
摘要：
One of the dogmas of transcriptional regulation in higher eukaryotes suggests the existence of transcriptional domains with no promoter-enhancer interactions between them. Specific regulatory elements, known as insulators, block the interaction between an enhancer and a promoter. Insulators are believed to act as transcription domain boundaries. The review considers general properties of well-known insulators identified in Drosophila and vertebrates. The mechanism of action of insulators and their role in the regulation of gene expression are discussed.
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页码：845 / 857
页数：12
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