xnd-1 regulates the global recombination landscape in Caenorhabditis elegans

被引：0
作者：
Cynthia R. Wagner
Lynnette Kuervers
David L. Baillie
Judith L. Yanowitz
机构：
[1] Carnegie Institution of Washington,Department of Embryology
[2] Simon Fraser University,undefined
[3] Dept. of Molecular Biology and Biochemistry,undefined
[4] Burnaby,undefined
[5] British Columbia V5A 1S6,undefined
[6] Canada ,undefined
[7] Magee-Womens Research Institute and University of Pittsburgh School of Medicine,undefined
[8] Dept. of Obstetrics,undefined
[9] Gynecology and Reproductive Sciences,undefined
[10] Pittsburgh,undefined
[11] Pennsylvania 15213,undefined
[12] USA ,undefined
[13] Current address: University of Maryland,undefined
[14] Baltimore County,undefined
[15] Dept. of Biological Sciences,undefined
[16] Baltimore,undefined
[17] Maryland 21250,undefined
[18] USA.,undefined
来源：
Nature | 2010年 / 467卷
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学科分类号：
摘要：
To facilitate their proper segregation, duplicated meiotic chromosomes are physically joined by crossovers. Crossover formation begins with the introduction of meiosis-specific double-strand breaks. In this study, Judith Yanowitz and colleagues identify a new gene in the nematode Caenorhabditis elegans, xnd-1, that is required for crossover distribution on both the X and autosomal chromosomes. Preliminary data suggest that xnd-1 does this by regulating acetylation of histone H2A on lysine 5.
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页码：839 / 843
页数：4
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