xnd-1 regulates the global recombination landscape in Caenorhabditis elegans

被引：0

作者：

Cynthia R. Wagner

Lynnette Kuervers

David L. Baillie

Judith L. Yanowitz

机构：

[1] Carnegie Institution of Washington,Department of Embryology

[2] Simon Fraser University,undefined

[3] Dept. of Molecular Biology and Biochemistry,undefined

[4] Burnaby,undefined

[5] British Columbia V5A 1S6,undefined

[6] Canada ,undefined

[7] Magee-Womens Research Institute and University of Pittsburgh School of Medicine,undefined

[8] Dept. of Obstetrics,undefined

[9] Gynecology and Reproductive Sciences,undefined

[10] Pittsburgh,undefined

[11] Pennsylvania 15213,undefined

[12] USA ,undefined

[13] Current address: University of Maryland,undefined

[14] Baltimore County,undefined

[15] Dept. of Biological Sciences,undefined

[16] Baltimore,undefined

[17] Maryland 21250,undefined

[18] USA.,undefined

来源：

Nature | 2010年 / 467卷

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摘要：

To facilitate their proper segregation, duplicated meiotic chromosomes are physically joined by crossovers. Crossover formation begins with the introduction of meiosis-specific double-strand breaks. In this study, Judith Yanowitz and colleagues identify a new gene in the nematode Caenorhabditis elegans, xnd-1, that is required for crossover distribution on both the X and autosomal chromosomes. Preliminary data suggest that xnd-1 does this by regulating acetylation of histone H2A on lysine 5.

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页码：839 / 843

页数：4

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