Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

被引:1193
作者
Li, Guangdi [1 ]
De Clercq, Erik [2 ]
机构
[1] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Peoples R China
[2] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol Immunol & Transplantat, Leuven, Belgium
关键词
D O I
10.1038/d41573-020-00016-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Therapeutic options in response to the 2019-nCoV outbreak are urgently needed. Here, we discuss the potential for repurposing existing antiviral agents to treat 2019-nCoV infection (now known as COVID-19), some of which are already moving into clinical trials.
引用
收藏
页码:149 / 150
页数:2
相关论文
共 6 条
[1]  
Clercq E, 2016, CLIN MICROBIOL REV, V29, P695, DOI DOI 10.1128/CMR.00102-15
[2]   New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections [J].
De Clercq, Erik .
CHEMISTRY-AN ASIAN JOURNAL, 2019, 14 (22) :3962-3968
[3]   First Case of 2019 Novel Coronavirus in the United States [J].
Holshue, Michelle L. ;
DeBolt, Chas ;
Lindquist, Scott ;
Lofy, Kathy H. ;
Wiesman, John ;
Bruce, Hollianne ;
Spitters, Christopher ;
Ericson, Keith ;
Wilkerson, Sara ;
Tural, Ahmet ;
Diaz, George ;
Cohn, Amanda ;
Fox, LeAnne ;
Patel, Anita ;
Gerber, Susan I. ;
Kim, Lindsay ;
Tong, Suxiang ;
Lu, Xiaoyan ;
Lindstrom, Steve ;
Pallansch, Mark A. ;
Weldon, William C. ;
Biggs, Holly M. ;
Uyeki, Timothy M. ;
Pillai, Satish K. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (10) :929-936
[4]   Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV [J].
Morse, Jared S. ;
Lalonde, Tyler ;
Xu, Shiqing ;
Liu, Wenshe Ray .
CHEMBIOCHEM, 2020, 21 (05) :730-738
[5]   Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro [J].
Wang, Manli ;
Cao, Ruiyuan ;
Zhang, Leike ;
Yang, Xinglou ;
Liu, Jia ;
Xu, Mingyue ;
Shi, Zhengli ;
Hu, Zhihong ;
Zhong, Wu ;
Xiao, Gengfu .
CELL RESEARCH, 2020, 30 (03) :269-271
[6]   Coronaviruses - drug discovery and therapeutic options [J].
Zumla, Alimuddin ;
Chan, Jasper F. W. ;
Azhar, Esam I. ;
Hui, David S. C. ;
Yuen, Kwok-Yung .
NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (05) :327-347