Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa

被引：32
作者：
Chaudhary M. [1 ]
Gadbail A.R. [1 ,4 ]
Vidhale G. [1 ]
Mankar M.P. [2 ]
Gondivkar S.M. [3 ]
Gawande M. [1 ]
Patil S. [1 ]
机构：
[1] Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha 442001 Maharashtra, Sawangi (Meghe)
[2] Department of Orthodontia, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha 442001 Maharashtra, Sawangi (Meghe)
[3] Department of Oral Diagnosis, Medicine and Radiology, MGV's K.B.H. Dental College and Hospital, Nashik, Maharashtra
[4] Nagpur 440009 Maharashtra, Plot No. 1, Shaktimata Nagar, Kharbi Rd., Behind Hanuman
来源：
Head and Neck Pathology | 2012年 / 6卷 / 3期
关键词：
Myofibroblast; Oral epithelial dysplasia; Oral premalignancy; Oral squamous cell carcinoma; Verrucous carcinoma; α-smooth muscle actin;
D O I：
10.1007/s12105-012-0335-x
中图分类号：
学科分类号：
摘要：
The aim was to evaluate and compare the presence of myofibroblasts in oral squamous cell carcinoma (OSCC), verrucous carcinoma (VC), high-risk epithelial dysplasia (HRED), low-risk epithelial dysplasia (LRED), and normal oral mucosa (NOM). The study consisted of 37 OSCC, 15 VC, 15 HRED, 15 LRED and 15 NOM. α-smooth muscle actin (α-SMA) antibody was used to identify myofibroblasts. The α-SMA expression was not observed in NOM and LRED. The α-SMA was expressed in 97.29% of OSCC, 86.66% of VC, 46.66 % of HRED. The α-SMA expression was significantly higher in OSCC than VC (p = 0.023) and HRED (p < 0.000). The α-SMA expression was significantly higher in VC than HRED (p = 0.043). Myofibroblastic expression, as highlighted by α-SMA, is undetectable in NOM and LRED but increases as the disease progresses from potentially malignant disorders, as HRED to VC to invasive OSCC. Thus, proliferation of myofibroblasts may be used as a stromal marker of oral premalignancy and malignancy. © 2012 Springer Science+Business Media, LLC.
引用
收藏
页码：305 / 313
页数：8
相关论文
共 42 条
[41]  
Sobral L.M., Montan P.F., Martelli-Junior H., Graner E., Coletta R.D., Opposite effects of TGF-beta1 and IFN-gamma on transdifferentiation of myofibroblast in human gingival cell cultures, J Clin Periodontol, 34, 5, pp. 397-406, (2007)
[42]  
Sobral L.M., Zecchin K.G., de Nascimento Aquino S., Lopes M.A., Graner E., Coletta R.D., Isolation and characterization of myofibroblast cell lines from oral squamous cell carcinoma, Oncol Rep, 25, 4, pp. 1013-1020, (2011)
12345