Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa

被引：32
作者：
Chaudhary M. [1 ]
Gadbail A.R. [1 ,4 ]
Vidhale G. [1 ]
Mankar M.P. [2 ]
Gondivkar S.M. [3 ]
Gawande M. [1 ]
Patil S. [1 ]
机构：
[1] Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha 442001 Maharashtra, Sawangi (Meghe)
[2] Department of Orthodontia, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha 442001 Maharashtra, Sawangi (Meghe)
[3] Department of Oral Diagnosis, Medicine and Radiology, MGV's K.B.H. Dental College and Hospital, Nashik, Maharashtra
[4] Nagpur 440009 Maharashtra, Plot No. 1, Shaktimata Nagar, Kharbi Rd., Behind Hanuman
来源：
Head and Neck Pathology | 2012年 / 6卷 / 3期
关键词：
Myofibroblast; Oral epithelial dysplasia; Oral premalignancy; Oral squamous cell carcinoma; Verrucous carcinoma; α-smooth muscle actin;
D O I：
10.1007/s12105-012-0335-x
中图分类号：
学科分类号：
摘要：
The aim was to evaluate and compare the presence of myofibroblasts in oral squamous cell carcinoma (OSCC), verrucous carcinoma (VC), high-risk epithelial dysplasia (HRED), low-risk epithelial dysplasia (LRED), and normal oral mucosa (NOM). The study consisted of 37 OSCC, 15 VC, 15 HRED, 15 LRED and 15 NOM. α-smooth muscle actin (α-SMA) antibody was used to identify myofibroblasts. The α-SMA expression was not observed in NOM and LRED. The α-SMA was expressed in 97.29% of OSCC, 86.66% of VC, 46.66 % of HRED. The α-SMA expression was significantly higher in OSCC than VC (p = 0.023) and HRED (p < 0.000). The α-SMA expression was significantly higher in VC than HRED (p = 0.043). Myofibroblastic expression, as highlighted by α-SMA, is undetectable in NOM and LRED but increases as the disease progresses from potentially malignant disorders, as HRED to VC to invasive OSCC. Thus, proliferation of myofibroblasts may be used as a stromal marker of oral premalignancy and malignancy. © 2012 Springer Science+Business Media, LLC.
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页码：305 / 313
页数：8
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