Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells

被引：0
作者：
Arthur A. Hurwitz
Stephanie K. Watkins
机构：
[1] National Cancer Institute,Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program
来源：
Cancer Immunology, Immunotherapy | 2012年 / 61卷
关键词：
Tumor microenvironment; T cell; Tolerance; Suppression; CITIM 2011;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.
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页码：289 / 293
页数：4
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